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ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB. Patel R, et al. Among authors: zechner r. Nature. 2022 Jun;606(7916):968-975. doi: 10.1038/s41586-022-04787-x. Epub 2022 Jun 8. Nature. 2022. PMID: 35676490 Free PMC article.
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase.
Gruber A, Cornaciu I, Lass A, Schweiger M, Poeschl M, Eder C, Kumari M, Schoiswohl G, Wolinski H, Kohlwein SD, Zechner R, Zimmermann R, Oberer M. Gruber A, et al. Among authors: zechner r. J Biol Chem. 2010 Apr 16;285(16):12289-98. doi: 10.1074/jbc.M109.064469. Epub 2010 Feb 17. J Biol Chem. 2010. PMID: 20164531 Free PMC article.
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. Haemmerle G, et al. Among authors: zechner r. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439. Nat Med. 2011. PMID: 21857651 Free PMC article.
The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.
Cornaciu I, Boeszoermenyi A, Lindermuth H, Nagy HM, Cerk IK, Ebner C, Salzburger B, Gruber A, Schweiger M, Zechner R, Lass A, Zimmermann R, Oberer M. Cornaciu I, et al. Among authors: zechner r. PLoS One. 2011;6(10):e26349. doi: 10.1371/journal.pone.0026349. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22039468 Free PMC article.
244 results