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Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution.
Dyer RP, Isoda HM, Salcedo GS, Speciale G, Fletcher MH, Le LQ, Liu Y, Brami-Cherrier K, Malik SZ, Vazquez-Cintron EJ, Chu AC, Rupp DC, Jacky BPS, Nguyen TTM, Katz BB, Steward LE, Majumdar S, Brideau-Andersen AD, Weiss GA. Dyer RP, et al. Among authors: le lq. Sci Rep. 2022 Jun 15;12(1):9956. doi: 10.1038/s41598-022-13617-z. Sci Rep. 2022. PMID: 35705606 Free PMC article.
Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1.
Sarin KY, Bradshaw M, O'Mara C, Shahryari J, Kincaid J, Kempers S, Tu JH, Dhawan S, DuBois J, Wilson D, Horwath P, de Souza MP, Powala C, Kochendoerfer GG, Plotkin SR, Webster GF, Le LQ. Sarin KY, et al. Among authors: le lq. Sci Adv. 2024 May 3;10(18):eadk4946. doi: 10.1126/sciadv.adk4946. Epub 2024 May 1. Sci Adv. 2024. PMID: 38691597 Free PMC article. Clinical Trial.
Stem cell modeling of nervous system tumors.
Furnari FB, Anastasaki C, Bian S, Fine HA, Koga T, Le LQ, Rodriguez FJ, Gutmann DH. Furnari FB, et al. Among authors: le lq. Dis Model Mech. 2024 Feb 1;17(2):dmm050533. doi: 10.1242/dmm.050533. Epub 2024 Feb 14. Dis Model Mech. 2024. PMID: 38353122 Free PMC article. Review.
Econazole selectively induces cell death in NF1-homozygous mutant tumor cells.
Lakes YB, Moye SL, Mo J, Tegtmeyer M, Nehme R, Charlton M, Salinas G, McKay RM, Eggan K, Le LQ. Lakes YB, et al. Among authors: le lq. Cell Rep Med. 2023 Dec 19;4(12):101309. doi: 10.1016/j.xcrm.2023.101309. Epub 2023 Dec 11. Cell Rep Med. 2023. PMID: 38086379 Free PMC article.
A Call for Discovery and Therapeutic Development for Cutaneous Neurofibromas.
Blakeley JO, Le LQ, Lee SY, Ly I, Rhodes SD, Romo CG, Sarin KY, Staedtke V, Steensma MR, Wolkenstein P; 2022 NTAP Cutaneous Neurofibroma Symposium Participants. Blakeley JO, et al. Among authors: le lq. J Invest Dermatol. 2023 Aug;143(8):1351-1357. doi: 10.1016/j.jid.2022.11.027. Epub 2023 Jun 21. J Invest Dermatol. 2023. PMID: 37354152 No abstract available.
89 results