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A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection.
Lawrence SP, Elser SE, Torben W, Blair RV, Pahar B, Aye PP, Schiro F, Szeltner D, Doyle-Meyers LA, Haggarty BS, Jordan APO, Romano J, Leslie GJ, Alvarez X, O'Connor DH, Wiseman RW, Fennessey CM, Li Y, Piatak M Jr, Lifson JD, LaBranche CC, Lackner AA, Keele BF, Maness NJ, Marsh M, Hoxie JA. Lawrence SP, et al. Among authors: alvarez x. PLoS Pathog. 2022 Jun 17;18(6):e1010507. doi: 10.1371/journal.ppat.1010507. eCollection 2022 Jun. PLoS Pathog. 2022. PMID: 35714165 Free PMC article.
Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M Jr, Lifson JD, Keele BF, Hoxie JA, Lackner AA. Breed MW, et al. Among authors: alvarez x. J Virol. 2013 Feb;87(3):1528-43. doi: 10.1128/JVI.01928-12. Epub 2012 Nov 14. J Virol. 2013. PMID: 23152518 Free PMC article.
Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway.
Mohan M, Aye PP, Borda JT, Alvarez X, Lackner AA. Mohan M, et al. Among authors: alvarez x. Am J Pathol. 2007 Dec;171(6):1952-65. doi: 10.2353/ajpath.2007.070017. Epub 2007 Nov 30. Am J Pathol. 2007. PMID: 18055558 Free PMC article.
CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier.
Borda JT, Alvarez X, Mohan M, Hasegawa A, Bernardino A, Jean S, Aye P, Lackner AA. Borda JT, et al. Among authors: alvarez x. Am J Pathol. 2008 Mar;172(3):725-37. doi: 10.2353/ajpath.2008.070848. Epub 2008 Feb 14. Am J Pathol. 2008. PMID: 18276779 Free PMC article.
230 results