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Page 1
Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model.
Freitag K, Sterczyk N, Wendlinger S, Obermayer B, Schulz J, Farztdinov V, Mülleder M, Ralser M, Houtman J, Fleck L, Braeuning C, Sansevrino R, Hoffmann C, Milovanovic D, Sigrist SJ, Conrad T, Beule D, Heppner FL, Jendrach M. Freitag K, et al. Among authors: sigrist sj. J Neuroinflammation. 2022 Jul 2;19(1):172. doi: 10.1186/s12974-022-02534-7. J Neuroinflammation. 2022. PMID: 35780157 Free PMC article.
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.
Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang Y, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, Küttner V, Wolinski H, Zimmermann A, Domuz Trifunović L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, Vögtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F. Ring J, et al. Among authors: sigrist sj. EMBO Mol Med. 2022 May 9;14(5):e13952. doi: 10.15252/emmm.202113952. Epub 2022 Apr 4. EMBO Mol Med. 2022. PMID: 35373908 Free PMC article.
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. Among authors: sigrist sj. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ. Gupta VK, et al. Among authors: sigrist sj. Nat Neurosci. 2013 Oct;16(10):1453-60. doi: 10.1038/nn.3512. Epub 2013 Sep 1. Nat Neurosci. 2013. PMID: 23995066
Spermidine-triggered autophagy ameliorates memory during aging.
Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F. Sigrist SJ, et al. Autophagy. 2014 Jan;10(1):178-9. doi: 10.4161/auto.26918. Epub 2013 Nov 15. Autophagy. 2014. PMID: 24262970 Free PMC article.
Spermidine protects against α-synuclein neurotoxicity.
Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A, Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist SJ, Madeo F. Büttner S, et al. Among authors: sigrist sj. Cell Cycle. 2014;13(24):3903-8. doi: 10.4161/15384101.2014.973309. Cell Cycle. 2014. PMID: 25483063 Free PMC article.
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Among authors: sigrist sj. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Spermidine boosts autophagy to protect from synapse aging.
Bhukel A, Madeo F, Sigrist SJ. Bhukel A, et al. Among authors: sigrist sj. Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. Epub 2016 Dec 27. Autophagy. 2017. PMID: 28026976 Free PMC article.
Dietary spermidine for lowering high blood pressure.
Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Among authors: sigrist sj. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. Autophagy. 2017. PMID: 28118075 Free PMC article.
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A. Schwarz C, et al. Among authors: sigrist sj. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. Aging (Albany NY). 2018. PMID: 29315079 Free PMC article. Clinical Trial.
174 results