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Modulating mitofusins to control mitochondrial function and signaling.
Zacharioudakis E, Agianian B, Kumar Mv V, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Mathew C, Wei P, Tsirigos A, Tait SWG, Kirshenbaum LA, Kitsis RN, Gavathiotis E. Zacharioudakis E, et al. Among authors: gavathiotis e. Nat Commun. 2022 Jul 7;13(1):3775. doi: 10.1038/s41467-022-31324-1. Nat Commun. 2022. PMID: 35798717 Free PMC article.
Bax regulates primary necrosis through mitochondrial dynamics.
Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW 2nd, O'Rourke B, Kitsis RN. Whelan RS, et al. Among authors: gavathiotis e. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71. doi: 10.1073/pnas.1201608109. Epub 2012 Apr 9. Proc Natl Acad Sci U S A. 2012. PMID: 22493254 Free PMC article.
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Barclay LA, et al. Among authors: gavathiotis e. Mol Cell. 2015 Mar 5;57(5):873-886. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12. Mol Cell. 2015. PMID: 25684204 Free PMC article.
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E. Garner TP, et al. Among authors: gavathiotis e. Mol Cell. 2016 Aug 4;63(3):485-97. doi: 10.1016/j.molcel.2016.06.010. Epub 2016 Jul 14. Mol Cell. 2016. PMID: 27425408 Free PMC article.
Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.
Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD. Johnson JL, et al. Among authors: gavathiotis e. J Biol Chem. 2016 Dec 9;291(50):25965-25982. doi: 10.1074/jbc.M116.741884. Epub 2016 Oct 4. J Biol Chem. 2016. PMID: 27702998 Free PMC article.
Correcting mitochondrial fusion by manipulating mitofusin conformations.
Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II. Franco A, et al. Among authors: gavathiotis e. Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24. Nature. 2016. PMID: 27775718 Free PMC article.
83 results