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Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B. Biermann J, et al. Among authors: lu c. Cell. 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007. Cell. 2022. PMID: 35803246 Free PMC article.
Oncohistones: Hijacking the histone code.
Sahu V, Lu C. Sahu V, et al. Among authors: lu c. Annu Rev Cancer Biol. 2022 Apr;6:293-312. doi: 10.1146/annurev-cancerbio-070120-102521. Epub 2022 Jan 18. Annu Rev Cancer Biol. 2022. PMID: 36589281 Free PMC article.
Induction of sarcomas by mutant IDH2.
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Lu C, et al. Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113. Genes Dev. 2013. PMID: 24065766 Free PMC article.
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Li Y, et al. Among authors: lu c. Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi: 10.1016/j.molcel.2022.09.007. Epub 2022 Oct 6. Mol Cell. 2022. PMID: 36206767 Free PMC article.
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.
Chen X, Li Y, Zhu F, Xu X, Estrella B, Pazos MA 2nd, McGuire JT, Karagiannis D, Sahu V, Mustafokulov M, Scuoppo C, Sánchez-Rivera FJ, Soto-Feliciano YM, Pasqualucci L, Ciccia A, Amengual JE, Lu C. Chen X, et al. Among authors: lu c. Nat Commun. 2023 Jul 17;14(1):4259. doi: 10.1038/s41467-023-39990-5. Nat Commun. 2023. PMID: 37460547 Free PMC article.
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Figueroa ME, et al. Among authors: lu c. Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9. Cancer Cell. 2010. PMID: 21130701 Free PMC article.
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