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PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses.
Bouzoni E, Perakakis N, Connelly MA, Angelidi AM, Pilitsi E, Farr O, Stefanakis K, Mantzoros CS. Bouzoni E, et al. Among authors: pilitsi e. Metabolism. 2022 Sep;134:155265. doi: 10.1016/j.metabol.2022.155265. Epub 2022 Jul 9. Metabolism. 2022. PMID: 35820631 Clinical Trial.
Circulating levels of the components of the GH/IGF-1/IGFBPs axis total and intact IGF-binding proteins (IGFBP) 3 and IGFBP 4 and total IGFBP 5, as well as PAPPA, PAPPA2 and Stanniocalcin-2 levels are not altered in response to energy deprivation and/or metreleptin administration in humans.
Pilitsi E, Peradze N, Perakakis N, Mantzoros CS. Pilitsi E, et al. Metabolism. 2019 Aug;97:32-39. doi: 10.1016/j.metabol.2019.05.004. Epub 2019 May 17. Metabolism. 2019. PMID: 31103608 Clinical Trial.
Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials.
Perakakis N, Kokkinos A, Peradze N, Tentolouris N, Ghaly W, Pilitsi E, Upadhyay J, Alexandrou A, Mantzoros CS. Perakakis N, et al. Among authors: pilitsi e. Metabolism. 2019 Dec;101:153997. doi: 10.1016/j.metabol.2019.153997. Epub 2019 Oct 28. Metabolism. 2019. PMID: 31672446 Clinical Trial.