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Broadly neutralizing antibodies target the coronavirus fusion peptide.
Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J. Dacon C, et al. Among authors: holbrook mr. Science. 2022 Aug 12;377(6607):728-735. doi: 10.1126/science.abq3773. Epub 2022 Jul 12. Science. 2022. PMID: 35857439 Free PMC article.
Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.
Johnson RF, Via LE, Kumar MR, Cornish JP, Yellayi S, Huzella L, Postnikova E, Oberlander N, Bartos C, Ork BL, Mazur S, Allan C, Holbrook MR, Solomon J, Johnson JC, Pickel J, Hensley LE, Jahrling PB. Johnson RF, et al. Among authors: holbrook mr. Virology. 2015 Nov;485:422-30. doi: 10.1016/j.virol.2015.07.013. Epub 2015 Sep 3. Virology. 2015. PMID: 26342468 Free PMC article.
3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.
Johnson RF, Bagci U, Keith L, Tang X, Mollura DJ, Zeitlin L, Qin J, Huzella L, Bartos CJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Paulty MH, Velasco J, Whaley KJ, Johnson JC, Pettitt J, Ork BL, Solomon J, Oberlander N, Zhu Q, Sun J, Holbrook MR, Olinger GG, Baric RS, Hensley LE, Jahrling PB, Marasco WA. Johnson RF, et al. Among authors: holbrook mr. Virology. 2016 Mar;490:49-58. doi: 10.1016/j.virol.2016.01.004. Epub 2016 Jan 30. Virology. 2016. PMID: 26828465 Free PMC article.
Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus.
Cong Y, Lentz MR, Lara A, Alexander I, Bartos C, Bohannon JK, Hammoud D, Huzella L, Jahrling PB, Janosko K, Jett C, Kollins E, Lackemeyer M, Mollura D, Ragland D, Rojas O, Solomon J, Xu Z, Munster V, Holbrook MR. Cong Y, et al. Among authors: holbrook mr. PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005532. doi: 10.1371/journal.pntd.0005532. eCollection 2017 Apr. PLoS Negl Trop Dis. 2017. PMID: 28388650 Free PMC article.
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.
DeWald LE, Dyall J, Sword JM, Torzewski L, Zhou H, Postnikova E, Kollins E, Alexander I, Gross R, Cong Y, Gerhardt DM, Johnson RF, Olinger GG Jr, Holbrook MR, Hensley LE, Jahrling PB. DeWald LE, et al. Among authors: holbrook mr. J Infect Dis. 2018 Nov 22;218(suppl_5):S588-S591. doi: 10.1093/infdis/jiy332. J Infect Dis. 2018. PMID: 29982632 Free PMC article.
Aerosol exposure to intermediate size Nipah virus particles induces neurological disease in African green monkeys.
Hammoud DA, Lentz MR, Lara A, Bohannon JK, Feuerstein I, Huzella L, Jahrling PB, Lackemeyer M, Laux J, Rojas O, Sayre P, Solomon J, Cong Y, Munster V, Holbrook MR. Hammoud DA, et al. Among authors: holbrook mr. PLoS Negl Trop Dis. 2018 Nov 21;12(11):e0006978. doi: 10.1371/journal.pntd.0006978. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30462637 Free PMC article.
150 results