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ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Among authors: chen kw. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.
Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. Conos SA, et al. Among authors: chen kw. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096356 Free PMC article.
Inflammasome and gasdermin signaling in neutrophils.
Yow SJ, Yeap HW, Chen KW. Yow SJ, et al. Among authors: chen kw. Mol Microbiol. 2022 May;117(5):961-972. doi: 10.1111/mmi.14891. Epub 2022 Mar 16. Mol Microbiol. 2022. PMID: 35244299 Free article. Review.
RIPK1 and RIPK3 in antibacterial defence.
Yeap HW, Chen KW. Yeap HW, et al. Among authors: chen kw. Biochem Soc Trans. 2022 Dec 16;50(6):1583-1594. doi: 10.1042/BST20211242. Biochem Soc Trans. 2022. PMID: 36421920 Review.
424 results