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ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14.
Science. 2022.
PMID: 35857590
Free PMC article.
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.
Robinson KS, Teo DET, Tan KS, Toh GA, Ong HH, Lim CK, Lay K, Au BV, Lew TS, Chu JJH, Chow VTK, Wang Y, Zhong FL, Reversade B.
Robinson KS, et al. Among authors: toh ga.
Science. 2020 Dec 4;370(6521):eaay2002. doi: 10.1126/science.aay2002. Epub 2020 Oct 22.
Science. 2020.
PMID: 33093214
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J.
Huang M, et al. Among authors: toh ga.
Nature. 2021 Apr;592(7856):773-777. doi: 10.1038/s41586-021-03320-w. Epub 2021 Mar 17.
Nature. 2021.
PMID: 33731929
Free PMC article.
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Viral proteases activate the CARD8 inflammasome in the human cardiovascular system.
Nadkarni R, Chu WC, Lee CQE, Mohamud Y, Yap L, Toh GA, Beh S, Lim R, Fan YM, Zhang YL, Robinson K, Tryggvason K, Luo H, Zhong F, Ho L.
Nadkarni R, et al. Among authors: toh ga.
J Exp Med. 2022 Oct 3;219(10):e20212117. doi: 10.1084/jem.20212117. Epub 2022 Sep 21.
J Exp Med. 2022.
PMID: 36129453
Free PMC article.
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EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption.
Pinilla M, Mazars R, Vergé R, Gorse L, Paradis M, Suire B, Santoni K, Robinson KS, Toh GA, Prouvensier L, Leon-Icaza SA, Hessel A, Péricat D, Murris M, Guet-Revillet H, Henras A, Buyck J, Ravet E, Zhong FL, Cougoule C, Planès R, Meunier E.
Pinilla M, et al. Among authors: toh ga.
J Exp Med. 2023 Oct 2;220(10):e20230104. doi: 10.1084/jem.20230104. Epub 2023 Aug 29.
J Exp Med. 2023.
PMID: 37642996
Free PMC article.
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Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.
Robinson KS, Toh GA, Firdaus MJ, Tham KC, Rozario P, Lim CK, Toh YX, Lau ZH, Binder SC, Mayer J, Bonnard C, Schmidt FI, Common JEA, Zhong FL.
Robinson KS, et al. Among authors: toh ga.
J Exp Med. 2023 Oct 2;220(10):e20230105. doi: 10.1084/jem.20230105. Epub 2023 Aug 29.
J Exp Med. 2023.
PMID: 37642997
Free PMC article.
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Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.
Rozario P, Pinilla M, Gorse L, Vind AC, Robinson KS, Toh GA, Firdaus MJ, Martínez JF, Kerk SK, Lin Z, Chambers JC, Bekker-Jensen S, Meunier E, Zhong F.
Rozario P, et al. Among authors: toh ga.
Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309579121. doi: 10.1073/pnas.2309579121. Epub 2024 Jan 4.
Proc Natl Acad Sci U S A. 2024.
PMID: 38175865
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