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ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Among authors: wu b. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.
Structural basis of RIP2 activation and signaling.
Gong Q, Long Z, Zhong FL, Teo DET, Jin Y, Yin Z, Boo ZZ, Zhang Y, Zhang J, Yang R, Bhushan S, Reversade B, Li Z, Wu B. Gong Q, et al. Among authors: wu b. Nat Commun. 2018 Nov 26;9(1):4993. doi: 10.1038/s41467-018-07447-9. Nat Commun. 2018. PMID: 30478312 Free PMC article.
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B. Gong Q, et al. Among authors: wu b. Nat Commun. 2021 Jan 8;12(1):188. doi: 10.1038/s41467-020-20319-5. Nat Commun. 2021. PMID: 33420028 Free PMC article.
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J. Huang M, et al. Among authors: wu b. Nature. 2021 Apr;592(7856):773-777. doi: 10.1038/s41586-021-03320-w. Epub 2021 Mar 17. Nature. 2021. PMID: 33731929 Free PMC article.
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B, Jovine L. Stsiapanava A, et al. Among authors: wu b. EMBO J. 2020 Dec 15;39(24):e106807. doi: 10.15252/embj.2020106807. Epub 2020 Nov 16. EMBO J. 2020. PMID: 33196145 Free PMC article.
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