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Preparing for the next pandemic: Simulation-based deep reinforcement learning to discover and test multimodal control of systemic inflammation using repurposed immunomodulatory agents.
Cockrell C, Larie D, An G. Cockrell C, et al. Among authors: an g. Front Immunol. 2022 Nov 21;13:995395. doi: 10.3389/fimmu.2022.995395. eCollection 2022. Front Immunol. 2022. PMID: 36479109 Free PMC article.
This proof-of-concept study determines if simulated sepsis (e.g. infection-driven cytokine storm) can be controlled in the absence of effective antimicrobial agents by targeting cytokines for which FDA-approved biologics currently exist. ...DRL training used a Deep Determi …
This proof-of-concept study determines if simulated sepsis (e.g. infection-driven cytokine storm) can be controlled in the absence of …
Toward mechanistic medical digital twins: some use cases in immunology.
Laubenbacher R, Adler F, An G, Castiglione F, Eubank S, Fonseca LL, Glazier J, Helikar T, Jett-Tilton M, Kirschner D, Macklin P, Mehrad B, Moore B, Pasour V, Shmulevich I, Smith A, Voigt I, Yankeelov TE, Ziemssen T. Laubenbacher R, et al. Among authors: an g. Front Digit Health. 2024 Mar 7;6:1349595. doi: 10.3389/fdgth.2024.1349595. eCollection 2024. Front Digit Health. 2024. PMID: 38515550 Free PMC article. Review.
Preparing for the next COVID: Deep Reinforcement Learning trained Artificial Intelligence discovery of multi-modal immunomodulatory control of systemic inflammation in the absence of effective anti-microbials.
Larie D, An G, Cockrell C. Larie D, et al. Among authors: an g. bioRxiv [Preprint]. 2022 Feb 18:2022.02.17.480940. doi: 10.1101/2022.02.17.480940. bioRxiv. 2022. PMID: 35194613 Free PMC article. Preprint.
The current work addresses the control problem of multi-modal, adaptive immunomodulation in the circumstance where there is no effective anti-pathogen therapy (e.g., in a novel viral pandemic or in the face of resistant microbes). ...We use as a surrogate system a previous …
The current work addresses the control problem of multi-modal, adaptive immunomodulation in the circumstance where there is no effective ant …
1,658 results