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A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.
Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, Nagarajan S, Diaz L, Sandborg H, Bhattacharyya S, Xia Z, Coussens LM, Tontonoz P, Sherman MH. Abrego J, et al. Among authors: tontonoz p. Cancer Discov. 2022 Oct 5;12(10):2414-2433. doi: 10.1158/2159-8290.CD-22-0661. Cancer Discov. 2022. PMID: 35894778 Free PMC article.
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Xiao X, et al. Among authors: tontonoz p. Nat Metab. 2023 Jan;5(1):165-181. doi: 10.1038/s42255-022-00722-6. Epub 2023 Jan 16. Nat Metab. 2023. PMID: 36646756 Free PMC article.
Licensing PPARγ to work in macrophages.
Villanueva CJ, Tontonoz P. Villanueva CJ, et al. Among authors: tontonoz p. Immunity. 2010 Nov 24;33(5):647-9. doi: 10.1016/j.immuni.2010.11.017. Immunity. 2010. PMID: 21094459 Free PMC article.
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. Villa GR, et al. Among authors: tontonoz p. Cancer Cell. 2016 Nov 14;30(5):683-693. doi: 10.1016/j.ccell.2016.09.008. Epub 2016 Oct 13. Cancer Cell. 2016. PMID: 27746144 Free PMC article.
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. Sandhu J, et al. Among authors: tontonoz p. Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13. Cell. 2018. PMID: 30220461 Free PMC article.
265 results