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Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Among authors: breukink e. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.
Lipid II as a target for antibiotics.
Breukink E, de Kruijff B. Breukink E, et al. Nat Rev Drug Discov. 2006 Apr;5(4):321-32. doi: 10.1038/nrd2004. Nat Rev Drug Discov. 2006. PMID: 16531990 Review.
The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci.
Arnusch CJ, Bonvin AM, Verel AM, Jansen WT, Liskamp RM, de Kruijff B, Pieters RJ, Breukink E. Arnusch CJ, et al. Among authors: breukink e. Biochemistry. 2008 Dec 2;47(48):12661-3. doi: 10.1021/bi801597b. Biochemistry. 2008. PMID: 18989934
Lipid II is a crucial component in bacterial cell wall synthesis [Breukink, E., et al. (1999) Science 286, 2361-2364]. It is the target of a number of important antibiotics, which include vancomycin and nisin [Breukink, E., and de Kruijff, B. (2006) Na …
Lipid II is a crucial component in bacterial cell wall synthesis [Breukink, E., et al. (1999) Science 286, 2361-2364]. It is t …
Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II.
Varney KM, Bonvin AM, Pazgier M, Malin J, Yu W, Ateh E, Oashi T, Lu W, Huang J, Diepeveen-de Buin M, Bryant J, Breukink E, Mackerell AD Jr, de Leeuw EP. Varney KM, et al. Among authors: breukink e. PLoS Pathog. 2013;9(11):e1003732. doi: 10.1371/journal.ppat.1003732. Epub 2013 Nov 7. PLoS Pathog. 2013. PMID: 24244161 Free PMC article.
High-resolution NMR studies of antibiotics in cellular membranes.
Medeiros-Silva J, Jekhmane S, Paioni AL, Gawarecka K, Baldus M, Swiezewska E, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: breukink e. Nat Commun. 2018 Sep 27;9(1):3963. doi: 10.1038/s41467-018-06314-x. Nat Commun. 2018. PMID: 30262913 Free PMC article.
Towards the Native Binding Modes of Antibiotics that Target Lipid II.
Medeiros-Silva J, Jekhmane S, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: breukink e. Chembiochem. 2019 Jul 15;20(14):1731-1738. doi: 10.1002/cbic.201800796. Epub 2019 May 22. Chembiochem. 2019. PMID: 30725496 Free PMC article. Review.
156 results