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Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper.
Illuzzi G, Staniszewska AD, Gill SJ, Pike A, McWilliams L, Critchlow SE, Cronin A, Fawell S, Hawthorne G, Jamal K, Johannes J, Leonard E, Macdonald R, Maglennon G, Nikkilä J, O'Connor MJ, Smith A, Southgate H, Wilson J, Yates J, Cosulich S, Leo E. Illuzzi G, et al. Among authors: macdonald r. Clin Cancer Res. 2022 Nov 1;28(21):4724-4736. doi: 10.1158/1078-0432.CCR-22-0301. Clin Cancer Res. 2022. PMID: 35929986 Free PMC article.
Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment.
Hamm G, Maglennon G, Williamson B, Macdonald R, Doherty A, Jones S, Harris J, Blades J, Harmer AR, Barton P, Rawlins PB, Smith P, Winter-Holt J, McMurray L, Johansson J, Fitzpatrick P, McCoull W, Coen M. Hamm G, et al. Among authors: macdonald r. Arch Toxicol. 2022 Feb;96(2):613-624. doi: 10.1007/s00204-021-03197-8. Epub 2022 Jan 1. Arch Toxicol. 2022. PMID: 34973110 Free PMC article.
Method to Investigate the Distribution of Water-Soluble Drug-Delivery Systems in Fresh Frozen Tissues Using Imaging Mass Cytometry.
Strittmatter N, England RM, Race AM, Sutton D, Moss JI, Maglennon G, Ling S, Wong E, Rose J, Purvis I, Macdonald R, Barry ST, Ashford MB, Goodwin RJA. Strittmatter N, et al. Among authors: macdonald r. Anal Chem. 2021 Mar 2;93(8):3742-3749. doi: 10.1021/acs.analchem.0c03908. Epub 2021 Feb 19. Anal Chem. 2021. PMID: 33606520
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Fogal V, Michopoulos F, Jarnuczak AF, Hamza GM, Harlfinger S, Davey P, Hulme H, Atkinson SJ, Gabrowski P, Cheung T, Grondine M, Hoover C, Rose J, Bray C, Foster AJ, Askin S, Majumder MM, Fitzpatrick P, Miele E, Macdonald R, Keun HC, Coen M. Fogal V, et al. Among authors: macdonald r. Arch Toxicol. 2024 May 17. doi: 10.1007/s00204-024-03771-w. Online ahead of print. Arch Toxicol. 2024. PMID: 38755480
Age-related dysregulation of the retinal transcriptome in African turquoise killifish.
Bergmans S, Noel NCL, Masin L, Harding EG, Krzywańska AM, De Schutter JD, Ayana R, Hu CK, Arckens L, Ruzycki PA, MacDonald RB, Clark BS, Moons L. Bergmans S, et al. Among authors: macdonald rb. Aging Cell. 2024 May 14:e14192. doi: 10.1111/acel.14192. Online ahead of print. Aging Cell. 2024. PMID: 38742929 Free article.
C9ORF72 deficiency results in neurodegeneration in the zebrafish retina.
Jaroszynska N, Salzinger A, Tsarouchas TM, Becker CG, Becker T, Lyons DA, MacDonald RB, Keatinge M. Jaroszynska N, et al. Among authors: macdonald rb. J Neurosci. 2024 Apr 24:e2128232024. doi: 10.1523/JNEUROSCI.2128-23.2024. Online ahead of print. J Neurosci. 2024. PMID: 38658168
2,577 results