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Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.
Cui Y, Lanne A, Peng X, Browne E, Bhatt A, Coltman NJ, Craven P, Cox LR, Cundy NJ, Dale K, Feula A, Frampton J, Fung M, Morton M, Goff A, Salih M, Lang X, Li X, Moon C, Pascoe J, Portman V, Press C, Schulz-Utermoehl T, Lee S, Tortorella MD, Tu Z, Underwood ZE, Wang C, Yoshizawa A, Zhang T, Waddell SJ, Bacon J, Alderwick L, Fossey JS, Neagoie C. Cui Y, et al. Among authors: underwood ze. J Med Chem. 2024 Feb 22;67(4):2529-2548. doi: 10.1021/acs.jmedchem.3c01643. Epub 2024 Feb 8. J Med Chem. 2024. PMID: 38331432 Free PMC article.
AZD4625 is a Potent and Selective Inhibitor of KRASG12C.
Chakraborty A, Hanson L, Robinson D, Lewis H, Bickerton S, Davies M, Polanski R, Whiteley R, Koers A, Atkinson J, Baker T, Del Barco Barrantes I, Ciotta G, Kettle JG, Magiera L, Martins CP, Peter A, Wigmore E, Underwood Z, Cosulich S, Niedbala M, Ross S. Chakraborty A, et al. Among authors: underwood z. Mol Cancer Ther. 2022 Oct 7;21(10):1535-1546. doi: 10.1158/1535-7163.MCT-22-0241. Mol Cancer Ther. 2022. PMID: 35930755 Free PMC article.
Hyperoxidation of Peroxiredoxins: Gain or Loss of Function?
Veal EA, Underwood ZE, Tomalin LE, Morgan BA, Pillay CS. Veal EA, et al. Among authors: underwood ze. Antioxid Redox Signal. 2018 Mar 1;28(7):574-590. doi: 10.1089/ars.2017.7214. Epub 2017 Sep 8. Antioxid Redox Signal. 2018. PMID: 28762774 Review.
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Tomalin LE, et al. Among authors: underwood ze. Free Radic Biol Med. 2016 Jun;95:333-48. doi: 10.1016/j.freeradbiomed.2016.02.035. Epub 2016 Mar 2. Free Radic Biol Med. 2016. PMID: 26944189 Free PMC article.