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IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.
Hale M, Netland J, Chen Y, Thouvenel CD, Smith KN, Rich LM, Vanderwall ER, Miranda MC, Eggenberger J, Hao L, Watson MJ, Mundorff CC, Rodda LB, King NP, Guttman M, Gale M, Abraham J, Debley JS, Pepper M, Rawlings DJ. Hale M, et al. Among authors: gale m. J Exp Med. 2022 Sep 5;219(9):e20220849. doi: 10.1084/jem.20220849. Epub 2022 Aug 8. J Exp Med. 2022. PMID: 35938988 Free PMC article.
The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
Suthar MS, Ramos HJ, Brassil MM, Netland J, Chappell CP, Blahnik G, McMillan A, Diamond MS, Clark EA, Bevan MJ, Gale M Jr. Suthar MS, et al. Among authors: gale m jr. Immunity. 2012 Aug 24;37(2):235-48. doi: 10.1016/j.immuni.2012.07.004. Epub 2012 Jul 26. Immunity. 2012. PMID: 22841161 Free PMC article.
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ. Gorman JA, et al. Among authors: gale m jr. Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29. Nat Immunol. 2017. PMID: 28553952 Free PMC article.
Risk of Zika microcephaly correlates with features of maternal antibodies.
Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N Jr, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA Jr, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R Jr, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M Jr, Rajagopal L, Adams Waldorf KM, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC. Robbiani DF, et al. Among authors: gale m jr. J Exp Med. 2019 Oct 7;216(10):2302-2315. doi: 10.1084/jem.20191061. Epub 2019 Aug 14. J Exp Med. 2019. PMID: 31413072 Free PMC article.
An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates.
Erasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH. Erasmus JH, et al. Among authors: gale m jr. Sci Transl Med. 2020 Aug 5;12(555):eabc9396. doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. Sci Transl Med. 2020. PMID: 32690628 Free PMC article.
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19.
Rodda LB, Netland J, Shehata L, Pruner KB, Morawski PM, Thouvenel C, Takehara KK, Eggenberger J, Hemann EA, Waterman HR, Fahning ML, Chen Y, Rathe J, Stokes C, Wrenn S, Fiala B, Carter LP, Hamerman JA, King NP, Gale M, Campbell DJ, Rawlings D, Pepper M. Rodda LB, et al. Among authors: gale m. medRxiv [Preprint]. 2020 Aug 15:2020.08.11.20171843. doi: 10.1101/2020.08.11.20171843. medRxiv. 2020. PMID: 32817957 Free PMC article. Updated. Preprint.
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19.
Rodda LB, Netland J, Shehata L, Pruner KB, Morawski PA, Thouvenel C, Takehara KK, Eggenberger J, Hemann E, Waterman HR, Fahning ML, Chen Y, Rathe J, Stokes C, Wrenn S, Fiala B, Carter L, Hamerman JA, King NP, Gale M Jr, Campbell DJ, Rawlings D, Pepper M. Rodda LB, et al. Among authors: gale m jr. Res Sq [Preprint]. 2020 Aug 13:rs.3.rs-57112. doi: 10.21203/rs.3.rs-57112/v1. Res Sq. 2020. PMID: 32818218 Free PMC article. Updated. Preprint.
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Corbett KS, Swanson PA 2nd, Padilla M, Neuzil KM, Bennett H, Leav B, Makowski M, Albert J, Cross K, Edara VV, Floyd K, Suthar MS, Martinez DR, Baric R, Buchanan W, Luke CJ, Phadke VK, Rostad CA, Ledgerwood JE, Graham BS, Beigel JH; mRNA-1273 Study Group. Anderson EJ, et al. N Engl J Med. 2020 Dec 17;383(25):2427-2438. doi: 10.1056/NEJMoa2028436. Epub 2020 Sep 29. N Engl J Med. 2020. PMID: 32991794 Free PMC article. Clinical Trial.
675 results