Grzesiek S - Search Results

1

Filling of a water-free void explains the allosteric regulation of the β₁-adrenergic receptor by cholesterol.

Abiko LA, Dias Teixeira R, Engilberge S, Grahl A, Mühlethaler T, Sharpe T, Grzesiek S. Abiko LA, et al. Among authors: grzesiek s. Nat Chem. 2022 Oct;14(10):1133-1141. doi: 10.1038/s41557-022-01009-9. Epub 2022 Aug 11. Nat Chem. 2022. PMID: 35953642

2

Key stabilizing elements of protein structure identified through pressure and temperature perturbation of its hydrogen bond network.

Nisius L, Grzesiek S. Nisius L, et al. Among authors: grzesiek s. Nat Chem. 2012 Sep;4(9):711-7. doi: 10.1038/nchem.1396. Epub 2012 Jul 8. Nat Chem. 2012. PMID: 22914191

3

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.

Isogai S, Deupi X, Opitz C, Heydenreich FM, Tsai CJ, Brueckner F, Schertler GF, Veprintsev DB, Grzesiek S. Isogai S, et al. Among authors: grzesiek s. Nature. 2016 Feb 11;530(7589):237-41. doi: 10.1038/nature16577. Epub 2016 Feb 3. Nature. 2016. PMID: 26840483 Free article.

4

Production of isotope-labeled proteins in insect cells for NMR.

Franke B, Opitz C, Isogai S, Grahl A, Delgado L, Gossert AD, Grzesiek S. Franke B, et al. Among authors: grzesiek s. J Biomol NMR. 2018 Jul;71(3):173-184. doi: 10.1007/s10858-018-0172-7. Epub 2018 Apr 23. J Biomol NMR. 2018. PMID: 29687312 Free article. Review.

5

High Pressure Shifts the β₁-Adrenergic Receptor to the Active Conformation in the Absence of G Protein.

Abiko LA, Grahl A, Grzesiek S. Abiko LA, et al. Among authors: grzesiek s. J Am Chem Soc. 2019 Oct 23;141(42):16663-16670. doi: 10.1021/jacs.9b06042. Epub 2019 Oct 11. J Am Chem Soc. 2019. PMID: 31564099

6

A high-resolution description of β₁-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR.

Grahl A, Abiko LA, Isogai S, Sharpe T, Grzesiek S. Grahl A, et al. Among authors: grzesiek s. Nat Commun. 2020 May 5;11(1):2216. doi: 10.1038/s41467-020-15864-y. Nat Commun. 2020. PMID: 32371991 Free PMC article.

7

Efficient production of a functional G protein-coupled receptor in E. coli for structural studies.

Abiko LA, Rogowski M, Gautier A, Schertler G, Grzesiek S. Abiko LA, et al. Among authors: grzesiek s. J Biomol NMR. 2021 Jan;75(1):25-38. doi: 10.1007/s10858-020-00354-6. Epub 2021 Jan 27. J Biomol NMR. 2021. PMID: 33501610 Free PMC article.

8

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.

Isaikina P, Tsai CJ, Dietz N, Pamula F, Grahl A, Goldie KN, Guixà-González R, Branco C, Paolini-Bertrand M, Calo N, Cerini F, Schertler GFX, Hartley O, Stahlberg H, Maier T, Deupi X, Grzesiek S. Isaikina P, et al. Among authors: grzesiek s. Sci Adv. 2021 Jun 16;7(25):eabg8685. doi: 10.1126/sciadv.abg8685. Print 2021 Jun. Sci Adv. 2021. PMID: 34134983 Free PMC article.

9

Nanobody GPS by PCS: An Efficient New NMR Analysis Method for G Protein Coupled Receptors and Other Large Proteins.

Wu FJ, Rieder PS, Abiko LA, Rößler P, Gossert AD, Häussinger D, Grzesiek S. Wu FJ, et al. Among authors: grzesiek s. J Am Chem Soc. 2022 Nov 30;144(47):21728-21740. doi: 10.1021/jacs.2c09692. Epub 2022 Nov 17. J Am Chem Soc. 2022. PMID: 36394272

10

NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.

Skora L, Mestan J, Fabbro D, Jahnke W, Grzesiek S. Skora L, et al. Among authors: grzesiek s. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4437-45. doi: 10.1073/pnas.1314712110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191057 Free PMC article.

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