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Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Ahangari F, et al. Among authors: backmark a. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1463-1479. doi: 10.1164/rccm.202010-3832OC. Am J Respir Crit Care Med. 2022. PMID: 35998281 Free PMC article.
The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.
Karusheva Y, Ratcliff M, Mörseburg A, Barker P, Melvin A, Sattar N, Burling K, Backmark A, Roth R, Jermutus L, Guiu-Jurado E, Blüher M, Welsh P, Hyvönen M, O'Rahilly S. Karusheva Y, et al. Among authors: backmark a. J Appl Lab Med. 2022 Oct 29;7(6):1388-1400. doi: 10.1093/jalm/jfac055. J Appl Lab Med. 2022. PMID: 35796717 Free article.
Affinity tags can reduce merohedral twinning of membrane protein crystals.
Backmark A, Nyblom M, Törnroth-Horsefield S, Kosinska-Eriksson U, Nordén K, Fellert M, Kjellbom P, Johanson U, Hedfalk K, Lindkvist-Petersson K, Neutze R, Horsefield R. Backmark A, et al. Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1183-6. doi: 10.1107/S090744490802948X. Epub 2008 Oct 18. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 19020358
High-resolution x-ray structure of human aquaporin 5.
Horsefield R, Nordén K, Fellert M, Backmark A, Törnroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U, Neutze R. Horsefield R, et al. Among authors: backmark a. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13327-32. doi: 10.1073/pnas.0801466105. Epub 2008 Sep 3. Proc Natl Acad Sci U S A. 2008. PMID: 18768791 Free PMC article.
Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Granberg KL, et al. Among authors: backmark a. J Med Chem. 2024 Mar 28;67(6):4419-4441. doi: 10.1021/acs.jmedchem.3c02184. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502782