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Page 1
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Ahangari F, et al. Among authors: kopf kw. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1463-1479. doi: 10.1164/rccm.202010-3832OC. Am J Respir Crit Care Med. 2022. PMID: 35998281 Free PMC article.
PTPα promotes fibroproliferative responses after acute lung injury.
Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. Aschner Y, et al. Among authors: kopf kw. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L69-L83. doi: 10.1152/ajplung.00436.2021. Epub 2022 Jun 7. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35670474 Free PMC article.
Cigarette smoke-induced airspace disease in mice develops independently of HIF-1α signaling in leukocytes.
Hume PS, McClendon J, Kopf KW, Harral JW, Poczobutt JM, McCubbrey AL, Smith BJ, Henson PM, Majka SM, Petrache I, Janssen WJ. Hume PS, et al. Among authors: kopf kw. Am J Physiol Lung Cell Mol Physiol. 2022 Oct 1;323(4):L391-L399. doi: 10.1152/ajplung.00491.2021. Epub 2022 Aug 9. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35943156 Free PMC article.
Iloprost requires the Frizzled-9 receptor to prevent lung cancer.
Sompel K, Dwyer-Nield LD, Smith AJ, Elango A, Backos DS, Zhang B, Gross J, Ternyak K, Matsuda JL, Kopf K, Keith RL, Tennis MA. Sompel K, et al. iScience. 2022 May 23;25(6):104442. doi: 10.1016/j.isci.2022.104442. eCollection 2022 Jun 17. iScience. 2022. PMID: 35707728 Free PMC article.
Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome.
Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Rizzo AN, et al. Among authors: kopf kw. JCI Insight. 2022 Jan 25;7(2):e154573. doi: 10.1172/jci.insight.154573. JCI Insight. 2022. PMID: 34874923 Free PMC article.
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