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Page 1
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.
Cantoni D, Murray MJ, Kalemera MD, Dicken SJ, Stejskal L, Brown G, Lytras S, Coey JD, McKenna J, Bridgett S, Simpson D, Fairley D, Thorne LG, Reuschl AK, Forrest C, Ganeshalingham M, Muir L, Palor M, Jarvis L, Willett B, Power UF, McCoy LE, Jolly C, Towers GJ, Doores KJ, Robertson DL, Shepherd AJ, Reeves MB, Bamford CGG, Grove J. Cantoni D, et al. Among authors: doores kj. EMBO Rep. 2022 Oct 6;23(10):e54322. doi: 10.15252/embr.202154322. Epub 2022 Sep 1. EMBO Rep. 2022. PMID: 35999696 Free PMC article.
Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings.
Pickering S, Betancor G, Galão RP, Merrick B, Signell AW, Wilson HD, Kia Ik MT, Seow J, Graham C, Acors S, Kouphou N, Steel KJA, Hemmings O, Patel A, Nebbia G, Douthwaite S, O'Connell L, Luptak J, McCoy LE, Brouwer P, van Gils MJ, Sanders RW, Martinez Nunez R, Bisnauthsing K, O'Hara G, MacMahon E, Batra R, Malim MH, Neil SJD, Doores KJ, Edgeworth JD. Pickering S, et al. Among authors: doores kj. PLoS Pathog. 2020 Sep 24;16(9):e1008817. doi: 10.1371/journal.ppat.1008817. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32970782 Free PMC article.
SARS-CoV-2 recruits a haem metabolite to evade antibody immunity.
Rosa A, Pye VE, Graham C, Muir L, Seow J, Ng KW, Cook NJ, Rees-Spear C, Parker E, Dos Santos MS, Rosadas C, Susana A, Rhys H, Nans A, Masino L, Roustan C, Christodoulou E, Ulferts R, Wrobel A, Short CE, Fertleman M, Sanders RW, Heaney J, Spyer M, Kjær S, Riddell A, Malim MH, Beale R, MacRae JI, Taylor GP, Nastouli E, van Gils MJ, Rosenthal PB, Pizzato M, McClure MO, Tedder RS, Kassiotis G, McCoy LE, Doores KJ, Cherepanov P. Rosa A, et al. Among authors: doores kj. medRxiv [Preprint]. 2021 Jan 26:2021.01.21.21249203. doi: 10.1101/2021.01.21.21249203. medRxiv. 2021. PMID: 33532784 Free PMC article. Updated. Preprint.
Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike.
Graham C, Seow J, Huettner I, Khan H, Kouphou N, Acors S, Winstone H, Pickering S, Galao RP, Lista MJ, Jimenez-Guardeno JM, Laing AG, Wu Y, Joseph M, Muir L, Ng WM, Duyvesteyn HME, Zhao Y, Bowden TA, Shankar-Hari M, Rosa A, Cherepanov P, McCoy LE, Hayday AC, Neil SJD, Malim MH, Doores KJ. Graham C, et al. Among authors: doores kj. bioRxiv [Preprint]. 2021 Feb 3:2021.02.03.429355. doi: 10.1101/2021.02.03.429355. bioRxiv. 2021. PMID: 33564766 Free PMC article. Updated. Preprint.
The effect of spike mutations on SARS-CoV-2 neutralization.
Rees-Spear C, Muir L, Griffith SA, Heaney J, Aldon Y, Snitselaar JL, Thomas P, Graham C, Seow J, Lee N, Rosa A, Roustan C, Houlihan CF, Sanders RW, Gupta RK, Cherepanov P, Stauss HJ, Nastouli E; SAFER Investigators; Doores KJ, van Gils MJ, McCoy LE. Rees-Spear C, et al. Among authors: doores kj. Cell Rep. 2021 Mar 23;34(12):108890. doi: 10.1016/j.celrep.2021.108890. Epub 2021 Mar 6. Cell Rep. 2021. PMID: 33713594 Free PMC article.
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.
Graham C, Seow J, Huettner I, Khan H, Kouphou N, Acors S, Winstone H, Pickering S, Galao RP, Dupont L, Lista MJ, Jimenez-Guardeño JM, Laing AG, Wu Y, Joseph M, Muir L, van Gils MJ, Ng WM, Duyvesteyn HME, Zhao Y, Bowden TA, Shankar-Hari M, Rosa A, Cherepanov P, McCoy LE, Hayday AC, Neil SJD, Malim MH, Doores KJ. Graham C, et al. Among authors: doores kj. Immunity. 2021 Jun 8;54(6):1276-1289.e6. doi: 10.1016/j.immuni.2021.03.023. Epub 2021 Apr 1. Immunity. 2021. PMID: 33836142 Free PMC article.
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Rosa A, Pye VE, Graham C, Muir L, Seow J, Ng KW, Cook NJ, Rees-Spear C, Parker E, Dos Santos MS, Rosadas C, Susana A, Rhys H, Nans A, Masino L, Roustan C, Christodoulou E, Ulferts R, Wrobel AG, Short CE, Fertleman M, Sanders RW, Heaney J, Spyer M, Kjær S, Riddell A, Malim MH, Beale R, MacRae JI, Taylor GP, Nastouli E, van Gils MJ, Rosenthal PB, Pizzato M, McClure MO, Tedder RS, Kassiotis G, McCoy LE, Doores KJ, Cherepanov P. Rosa A, et al. Among authors: doores kj. Sci Adv. 2021 May 28;7(22):eabg7607. doi: 10.1126/sciadv.abg7607. Print 2021 May. Sci Adv. 2021. PMID: 33888467 Free PMC article.
Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study.
Pickering S, Batra R, Merrick B, Snell LB, Nebbia G, Douthwaite S, Reid F, Patel A, Kia Ik MT, Patel B, Charalampous T, Alcolea-Medina A, Lista MJ, Cliff PR, Cunningham E, Mullen J, Doores KJ, Edgeworth JD, Malim MH, Neil SJD, Galão RP. Pickering S, et al. Among authors: doores kj. Lancet Microbe. 2021 Sep;2(9):e461-e471. doi: 10.1016/S2666-5247(21)00143-9. Epub 2021 Jun 30. Lancet Microbe. 2021. PMID: 34226893 Free PMC article.
Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern.
Dupont L, Snell LB, Graham C, Seow J, Merrick B, Lechmere T, Maguire TJA, Hallett SR, Pickering S, Charalampous T, Alcolea-Medina A, Huettner I, Jimenez-Guardeño JM, Acors S, Almeida N, Cox D, Dickenson RE, Galao RP, Kouphou N, Lista MJ, Ortega-Prieto AM, Wilson H, Winstone H, Fairhead C, Su JZ, Nebbia G, Batra R, Neil S, Shankar-Hari M, Edgeworth JD, Malim MH, Doores KJ. Dupont L, et al. Among authors: doores kj. Nat Microbiol. 2021 Nov;6(11):1433-1442. doi: 10.1038/s41564-021-00974-0. Epub 2021 Oct 15. Nat Microbiol. 2021. PMID: 34654917 Free PMC article.
114 results