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NAD precursors cycle between host tissues and the gut microbiome.
Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, Davidson SM, Thaiss CA, Migaud ME, Rabinowitz JD, Baur JA. Chellappa K, et al. Among authors: mcreynolds mr. Cell Metab. 2022 Dec 6;34(12):1947-1959.e5. doi: 10.1016/j.cmet.2022.11.004. Cell Metab. 2022. PMID: 36476934 Free PMC article.
Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging.
Vue Z, Neikirk K, Vang L, Garza-Lopez E, Christensen TA, Shao J, Lam J, Beasley HK, Marshall AG, Crabtree A, Anudokem J Jr, Rodriguez B, Kirk B, Bacevac S, Barongan T, Shao B, Stephens DC, Kabugi K, Koh HJ, Koh A, Evans CS, Taylor B, Reddy AK, Miller-Fleming T, Actkins KV, Zaganjor E, Daneshgar N, Murray SA, Mobley BC, Damo SM, Gaddy JA, Riggs B, Wanjalla C, Kirabo A, McReynolds M, Gomez JA, Phillips MA, Exil V, Dai DF, Hinton A Jr. Vue Z, et al. Am J Physiol Heart Circ Physiol. 2023 Nov 1;325(5):H965-H982. doi: 10.1152/ajpheart.00202.2023. Epub 2023 Aug 25. Am J Physiol Heart Circ Physiol. 2023. PMID: 37624101 Free PMC article.
Toying with reductive stress.
Murphy AC, McReynolds MR. Murphy AC, et al. Among authors: mcreynolds mr. Nat Chem Biol. 2024 May;20(5):542-543. doi: 10.1038/s41589-023-01461-9. Nat Chem Biol. 2024. PMID: 37884808 No abstract available.
Age-related NAD+ decline.
McReynolds MR, Chellappa K, Baur JA. McReynolds MR, et al. Exp Gerontol. 2020 Feb 22;134:110888. doi: 10.1016/j.exger.2020.110888. Online ahead of print. Exp Gerontol. 2020. PMID: 32097708 Free PMC article. Review.
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Among authors: mcreynolds mr. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
NAD+ flux is maintained in aged mice despite lower tissue concentrations.
McReynolds MR, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps HC, Mukherjee S, Bhat YR, Lingala SR, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss CA, Lu W, Migaud ME, Su X, Rabinowitz JD, Baur JA. McReynolds MR, et al. Cell Syst. 2021 Dec 15;12(12):1160-1172.e4. doi: 10.1016/j.cels.2021.09.001. Epub 2021 Sep 23. Cell Syst. 2021. PMID: 34559996 Free PMC article.
57 results