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JAG1-NOTCH4 mechanosensing drives atherosclerosis.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC. Souilhol C, et al. Among authors: fang y. Sci Adv. 2022 Sep 2;8(35):eabo7958. doi: 10.1126/sciadv.abo7958. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044575 Free PMC article.
Targeted polyelectrolyte complex micelles treat vascular complications in vivo.
Zhou Z, Yeh CF, Mellas M, Oh MJ, Zhu J, Li J, Huang RT, Harrison DL, Shentu TP, Wu D, Lueckheide M, Carver L, Chung EJ, Leon L, Yang KC, Tirrell MV, Fang Y. Zhou Z, et al. Among authors: fang y. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2114842118. doi: 10.1073/pnas.2114842118. Proc Natl Acad Sci U S A. 2021. PMID: 34880134 Free PMC article.
The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. Mehta V, et al. Among authors: fang y. Nature. 2020 Feb;578(7794):290-295. doi: 10.1038/s41586-020-1979-4. Epub 2020 Feb 5. Nature. 2020. PMID: 32025034 Free PMC article.
NOTCH1 is a mechanosensor in adult arteries.
Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. Mack JJ, et al. Among authors: fang y. Nat Commun. 2017 Nov 20;8(1):1620. doi: 10.1038/s41467-017-01741-8. Nat Commun. 2017. PMID: 29158473 Free PMC article.
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