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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
García-Alonso S, Mesa P, Ovejero LP, Aizpurua G, Lechuga CG, Zarzuela E, Santiveri CM, Sanclemente M, Muñoz J, Musteanu M, Campos-Olivas R, Martínez-Torrecuadrada J, Barbacid M, Montoya G. García-Alonso S, et al. Among authors: munoz j. Mol Cell. 2022 Sep 15;82(18):3438-3452.e8. doi: 10.1016/j.molcel.2022.08.012. Epub 2022 Sep 1. Mol Cell. 2022. PMID: 36055235 Free article.
USP7 limits CDK1 activity throughout the cell cycle.
Galarreta A, Valledor P, Ubieto-Capella P, Lafarga V, Zarzuela E, Muñoz J, Malumbres M, Lecona E, Fernandez-Capetillo O. Galarreta A, et al. Among authors: munoz j. EMBO J. 2021 Jun 1;40(11):e99692. doi: 10.15252/embj.201899692. Epub 2021 Apr 15. EMBO J. 2021. PMID: 33856059 Free PMC article.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A. de la Calle Arregui C, et al. Among authors: munoz j. Nat Commun. 2021 Jun 16;12(1):3660. doi: 10.1038/s41467-021-23857-8. Nat Commun. 2021. PMID: 34135321 Free PMC article.
KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform.
Salmón M, Paniagua G, Lechuga CG, Fernández-García F, Zarzuela E, Álvarez-Díaz R, Musteanu M, Guerra C, Caleiras E, Muñoz J, Ortega S, Drosten M, Barbacid M. Salmón M, et al. Among authors: munoz j. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023112118. doi: 10.1073/pnas.2023112118. Proc Natl Acad Sci U S A. 2021. PMID: 34301865 Free PMC article.
Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
Villarroya-Beltri C, Martins AFB, García A, Giménez D, Zarzuela E, Novo M, Del Álamo C, González-Martínez J, Bonel-Pérez GC, Díaz I, Guillamot M, Chiesa M, Losada A, Graña-Castro O, Rovira M, Muñoz J, Salazar-Roa M, Malumbres M. Villarroya-Beltri C, et al. Among authors: munoz j. EMBO J. 2023 Jan 4;42(1):e111251. doi: 10.15252/embj.2022111251. Epub 2022 Nov 3. EMBO J. 2023. PMID: 36326833 Free PMC article.
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. Sanz-Castillo B, et al. Among authors: munoz j. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. EMBO J. 2023. PMID: 36354735 Free PMC article.
2,519 results