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The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Richards CM, et al. Among authors: widen jc. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. Science. 2022. PMID: 36074821 Free PMC article.
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
Steuten K, Kim H, Widen JC, Babin BM, Onguka O, Lovell S, Bolgi O, Cerikan B, Neufeldt CJ, Cortese M, Muir RK, Bennett JM, Geiss-Friedlander R, Peters C, Bartenschlager R, Bogyo M. Steuten K, et al. Among authors: widen jc. ACS Infect Dis. 2021 Jun 11;7(6):1457-1468. doi: 10.1021/acsinfecdis.0c00815. Epub 2021 Feb 11. ACS Infect Dis. 2021. PMID: 33570381 Free PMC article.
AND-gate contrast agents for enhanced fluorescence-guided surgery.
Widen JC, Tholen M, Yim JJ, Antaris A, Casey KM, Rogalla S, Klaassen A, Sorger J, Bogyo M. Widen JC, et al. Nat Biomed Eng. 2021 Mar;5(3):264-277. doi: 10.1038/s41551-020-00616-6. Epub 2020 Sep 28. Nat Biomed Eng. 2021. PMID: 32989286 Free PMC article.
A redox economical synthesis of bioactive 6,12-guaianolides.
Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. Wen B, et al. Among authors: widen jc. Org Lett. 2013 Jun 7;15(11):2644-7. doi: 10.1021/ol400904y. Epub 2013 May 10. Org Lett. 2013. PMID: 23662902 Free PMC article.
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Kempema AM, et al. Among authors: widen jc. Bioorg Med Chem. 2015 Aug 1;23(15):4737-4745. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30. Bioorg Med Chem. 2015. PMID: 26088334 Free PMC article.
16 results