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Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Ku Z, Xie X, Lin J, Gao P, Wu B, El Sahili A, Su H, Liu Y, Ye X, Tan EY, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Zou J, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z. Ku Z, et al. Among authors: muruato ae. Nat Commun. 2022 Sep 22;13(1):5552. doi: 10.1038/s41467-022-33284-y. Nat Commun. 2022. PMID: 36138032 Free PMC article.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Johnson BA, Xie X, Bailey AL, Kalveram B, Lokugamage KG, Muruato A, Zou J, Zhang X, Juelich T, Smith JK, Zhang L, Bopp N, Schindewolf C, Vu M, Vanderheiden A, Winkler ES, Swetnam D, Plante JA, Aguilar P, Plante KS, Popov V, Lee B, Weaver SC, Suthar MS, Routh AL, Ren P, Ku Z, An Z, Debbink K, Diamond MS, Shi PY, Freiberg AN, Menachery VD. Johnson BA, et al. Nature. 2021 Mar;591(7849):293-299. doi: 10.1038/s41586-021-03237-4. Epub 2021 Jan 25. Nature. 2021. PMID: 33494095 Free PMC article.
Spike mutation D614G alters SARS-CoV-2 fitness.
Plante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY. Plante JA, et al. Among authors: muruato ae. Nature. 2021 Apr;592(7852):116-121. doi: 10.1038/s41586-020-2895-3. Epub 2020 Oct 26. Nature. 2021. PMID: 33106671 Free PMC article.
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
Ku Z, Xie X, Davidson E, Ye X, Su H, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z. Ku Z, et al. Among authors: muruato ae. Nat Commun. 2021 Jan 20;12(1):469. doi: 10.1038/s41467-020-20789-7. Nat Commun. 2021. PMID: 33473140 Free PMC article.
Engineering SARS-CoV-2 using a reverse genetic system.
Xie X, Lokugamage KG, Zhang X, Vu MN, Muruato AE, Menachery VD, Shi PY. Xie X, et al. Among authors: muruato ae. Nat Protoc. 2021 Mar;16(3):1761-1784. doi: 10.1038/s41596-021-00491-8. Epub 2021 Jan 29. Nat Protoc. 2021. PMID: 33514944 Free PMC article. Review.
Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.
Ku Z, Xie X, Hinton PR, Liu X, Ye X, Muruato AE, Ng DC, Biswas S, Zou J, Liu Y, Pandya D, Menachery VD, Rahman S, Cao YA, Deng H, Xiong W, Carlin KB, Liu J, Su H, Haanes EJ, Keyt BA, Zhang N, Carroll SF, Shi PY, An Z. Ku Z, et al. Among authors: muruato ae. Nature. 2021 Jul;595(7869):718-723. doi: 10.1038/s41586-021-03673-2. Epub 2021 Jun 3. Nature. 2021. PMID: 34082438 Free PMC article.
Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
Ku Z, Xie X, Davidson E, Ye X, Su H, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z. Ku Z, et al. Among authors: muruato ae. Nat Commun. 2021 Jul 1;12(1):4177. doi: 10.1038/s41467-021-24440-x. Nat Commun. 2021. PMID: 34210985 Free PMC article. No abstract available.
46 results