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Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination.
Stone VM, Utorova R, Butrym M, Sioofy-Khojine AB, Hankaniemi MM, Ringqvist EE, Blanter M, Parajuli A, Pincikova T, Fischler B, Karpati F, Hytönen VP, Hyöty H, Hjelte L, Flodström-Tullberg M. Stone VM, et al. Among authors: hyoty h. iScience. 2022 Sep 5;25(10):105070. doi: 10.1016/j.isci.2022.105070. eCollection 2022 Oct 21. iScience. 2022. PMID: 36157581 Free PMC article.
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes.
Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H. Laitinen OH, et al. Among authors: hyoty h. Diabetes. 2014 Feb;63(2):446-55. doi: 10.2337/db13-0619. Epub 2013 Aug 23. Diabetes. 2014. PMID: 23974921
Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes.
Oikarinen S, Tauriainen S, Hober D, Lucas B, Vazeou A, Sioofy-Khojine A, Bozas E, Muir P, Honkanen H, Ilonen J, Knip M, Keskinen P, Saha MT, Huhtala H, Stanway G, Bartsocas C, Ludvigsson J, Taylor K, Hyöty H; VirDiab Study Group. Oikarinen S, et al. Among authors: hyoty h. Diabetes. 2014 Feb;63(2):655-62. doi: 10.2337/db13-0620. Epub 2013 Sep 5. Diabetes. 2014. PMID: 24009257
Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G. Anagandula M, et al. Among authors: hyoty h. J Med Virol. 2014 Aug;86(8):1402-11. doi: 10.1002/jmv.23835. Epub 2013 Nov 19. J Med Virol. 2014. PMID: 24249667
A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.
Larsson PG, Lakshmikanth T, Laitinen OH, Utorova R, Jacobson S, Oikarinen M, Domsgen E, Koivunen MR, Chaux P, Devard N, Lecouturier V, Almond J, Knip M, Hyöty H, Flodström-Tullberg M. Larsson PG, et al. Among authors: hyoty h. Diabetologia. 2015 Feb;58(2):346-54. doi: 10.1007/s00125-014-3436-0. Epub 2014 Nov 5. Diabetologia. 2015. PMID: 25370797
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.
Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H. Honkanen H, et al. Among authors: hyoty h. Diabetologia. 2017 Mar;60(3):424-431. doi: 10.1007/s00125-016-4177-z. Epub 2017 Jan 9. Diabetologia. 2017. PMID: 28070615
395 results