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Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Cancer Discov. 2022 Dec 2;12(12):2774-2799. doi: 10.1158/2159-8290.CD-22-0192.
Cancer Discov. 2022.
PMID: 36165893
Free PMC article.
IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
Somani VK, Zhang D, Dodhiawala PB, Lander VE, Liu X, Kang LI, Chen HP, Knolhoff BL, Li L, Grierson PM, Ruzinova MB, DeNardo DG, Lim KH.
Somani VK, et al. Among authors: lander ve.
Gastroenterology. 2022 Jun;162(7):2047-2062. doi: 10.1053/j.gastro.2022.02.035. Epub 2022 Mar 7.
Gastroenterology. 2022.
PMID: 35271824
Free PMC article.
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Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy.
Zuo C, Baer JM, Knolhoff BL, Belle JI, Liu X, Alarcon De La Lastra A, Fu C, Hogg GD, Kingston NL, Breden MA, Dodhiawala PB, Zhou DC, Lander VE, James CA, Ding L, Lim KH, Fields RC, Hawkins WG, Weber JD, Zhao G, DeNardo DG.
Zuo C, et al. Among authors: lander ve.
J Exp Med. 2023 Jun 5;220(6):e20212062. doi: 10.1084/jem.20212062. Epub 2023 Mar 23.
J Exp Med. 2023.
PMID: 36951731
Free PMC article.
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Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer.
James CA, Baer JM, Zou C, Panni UY, Knolhoff BL, Hogg GD, Kingston NL, Kang LI, Lander VE, Luo J, Tao Y, Watson MA, Aft R, Fields RC, Hawkins WG, DeNardo DG.
James CA, et al. Among authors: lander ve.
Cancer Immunol Res. 2023 Aug 3;11(8):1055-1067. doi: 10.1158/2326-6066.CIR-21-0946.
Cancer Immunol Res. 2023.
PMID: 37229629
Free PMC article.
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Liu X, Hogg GD, Zuo C, Borcherding NC, Baer JM, Lander VE, Kang LI, Knolhoff BL, Ahmad F, Osterhout RE, Galkin AV, Bruey JM, Carter LL, Mpoy C, Vij KR, Fields RC, Schwarz JK, Park H, Gupta V, DeNardo DG.
Liu X, et al. Among authors: lander ve.
Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12. doi: 10.1016/j.ccell.2023.04.018. Epub 2023 May 25.
Cancer Cell. 2023.
PMID: 37236195
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Pancreatic Cancer's PD1-Roadblock: When T-Cell Reinvigoration Is Not Enough.
Lander VE, DeNardo DG.
Lander VE, et al.
Clin Cancer Res. 2024 Feb 1;30(3):474-476. doi: 10.1158/1078-0432.CCR-23-2991.
Clin Cancer Res. 2024.
PMID: 38038687
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Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer.
Belle JI, Sen D, Baer JM, Liu X, Lander VE, Ye J, Sells BE, Knolhoff BL, Faiz A, Kang LI, Qian G, Fields RC, Ding L, Kim H, Provenzano PP, Stewart SA, DeNardo DG.
Belle JI, et al. Among authors: lander ve.
Cancer Discov. 2024 Apr 29. doi: 10.1158/2159-8290.CD-23-0428. Online ahead of print.
Cancer Discov. 2024.
PMID: 38683144
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Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer.
Belle JI, Sen D, Baer JM, Liu X, Lander VE, Ye J, Sells BE, Knolhoff BL, Faiz A, Kang LI, Qian G, Fields RC, Ding L, Kim H, Provenzano PP, Stewart SA, DeNardo DG.
Belle JI, et al. Among authors: lander ve.
Cancer Discov. 2024 Apr 29:OF1-OF32. doi: 10.1158/2159-8290.CD-23-0428. Online ahead of print.
Cancer Discov. 2024.
PMID: 38683683
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