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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Wu HY, et al. Among authors: hyman bt. J Neurosci. 2010 Feb 17;30(7):2636-49. doi: 10.1523/JNEUROSCI.4456-09.2010. J Neurosci. 2010. PMID: 20164348 Free PMC article.
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.
Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Serrano-Pozo A, et al. Among authors: hyman bt. Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):220-6. doi: 10.1097/WAD.0b013e3181d61fea. Alzheimer Dis Assoc Disord. 2010. PMID: 20473136 Free PMC article. Clinical Trial.
Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. DaRocha-Souto B, et al. Among authors: hyman bt. J Neuropathol Exp Neurol. 2011 May;70(5):360-76. doi: 10.1097/NEN.0b013e318217a118. J Neuropathol Exp Neurol. 2011. PMID: 21487307 Free PMC article.
Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.
DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. DaRocha-Souto B, et al. Among authors: hyman bt. Neurobiol Dis. 2012 Jan;45(1):425-37. doi: 10.1016/j.nbd.2011.09.002. Epub 2011 Sep 13. Neurobiol Dis. 2012. PMID: 21945540 Free PMC article.
Neuropathological alterations in Alzheimer disease.
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Serrano-Pozo A, et al. Among authors: hyman bt. Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189. doi: 10.1101/cshperspect.a006189. Cold Spring Harb Perspect Med. 2011. PMID: 22229116 Free PMC article. Review.
833 results