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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Avar M, Heinzer D, Thackray AM, Liu Y, Hruska-Plochan M, Sellitto S, Schaper E, Pease DP, Yin JA, Lakkaraju AK, Emmenegger M, Losa M, Chincisan A, Hornemann S, Polymenidou M, Bujdoso R, Aguzzi A. Avar M, et al. Among authors: hornemann s. EMBO J. 2022 Dec 1;41(23):e112338. doi: 10.15252/embj.2022112338. Epub 2022 Oct 18. EMBO J. 2022. PMID: 36254605 Free PMC article.
Strain fidelity of chronic wasting disease upon murine adaptation.
Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. Sigurdson CJ, et al. Among authors: hornemann s. J Virol. 2006 Dec;80(24):12303-11. doi: 10.1128/JVI.01120-06. Epub 2006 Oct 4. J Virol. 2006. PMID: 17020952 Free PMC article.
Prion strain discrimination using luminescent conjugated polymers.
Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Sigurdson CJ, et al. Among authors: hornemann s. Nat Methods. 2007 Dec;4(12):1023-30. doi: 10.1038/nmeth1131. Epub 2007 Nov 18. Nat Methods. 2007. PMID: 18026110
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.
Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A. Margalith I, et al. Among authors: hornemann s. J Biol Chem. 2012 Jun 1;287(23):18872-87. doi: 10.1074/jbc.M112.355958. Epub 2012 Apr 6. J Biol Chem. 2012. PMID: 22493452 Free PMC article.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A. Sonati T, et al. Among authors: hornemann s. Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31. Nature. 2013. PMID: 23903654 Free article.
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.
Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ. Kurt TD, et al. Among authors: hornemann s. J Neurosci. 2014 Jan 15;34(3):1022-7. doi: 10.1523/JNEUROSCI.4636-13.2014. J Neurosci. 2014. PMID: 24431459 Free PMC article.
Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Herrmann US, et al. Among authors: hornemann s. PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25710374 Free PMC article.
Differential Toxicity of Antibodies to the Prion Protein.
Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A. Reimann RR, et al. Among authors: hornemann s. PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26821311 Free PMC article.
104 results