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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Avar M, Heinzer D, Thackray AM, Liu Y, Hruska-Plochan M, Sellitto S, Schaper E, Pease DP, Yin JA, Lakkaraju AK, Emmenegger M, Losa M, Chincisan A, Hornemann S, Polymenidou M, Bujdoso R, Aguzzi A. Avar M, et al. Among authors: lakkaraju ak. EMBO J. 2022 Dec 1;41(23):e112338. doi: 10.15252/embj.2022112338. Epub 2022 Oct 18. EMBO J. 2022. PMID: 36254605 Free PMC article.
A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
Characterization of APOBEC3G binding to 7SL RNA.
Bach D, Peddi S, Mangeat B, Lakkaraju A, Strub K, Trono D. Bach D, et al. Retrovirology. 2008 Jul 2;5:54. doi: 10.1186/1742-4690-5-54. Retrovirology. 2008. PMID: 18597676 Free PMC article.
Calreticulin mutations affect its chaperone function and perturb the glycoproteome.
Schürch PM, Malinovska L, Hleihil M, Losa M, Hofstetter MC, Wildschut MHE, Lysenko V, Lakkaraju AKK, Maat CA, Benke D, Aguzzi A, Wollscheid B, Picotti P, Theocharides APA. Schürch PM, et al. Among authors: lakkaraju akk. Cell Rep. 2022 Nov 22;41(8):111689. doi: 10.1016/j.celrep.2022.111689. Cell Rep. 2022. PMID: 36417879 Free article.
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.
Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR. Ackerman SD, et al. Among authors: lakkaraju akk. J Exp Med. 2018 Mar 5;215(3):941-961. doi: 10.1084/jem.20161714. Epub 2018 Jan 24. J Exp Med. 2018. PMID: 29367382 Free PMC article.
21 results