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SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.
Llorca-Cardenosa MJ, Aronson LI, Krastev DB, Nieminuszczy J, Alexander J, Song F, Dylewska M, Broderick R, Brough R, Zimmermann A, Zenke FT, Gurel B, Riisnaes R, Ferreira A, Roumeliotis T, Choudhary J, Pettitt SJ, de Bono J, Cervantes A, Haider S, Niedzwiedz W, Lord CJ, Chong IY. Llorca-Cardenosa MJ, et al. Among authors: lord cj. Cancer Res. 2022 Nov 2;82(21):3962-3973. doi: 10.1158/0008-5472.CAN-21-4339. Cancer Res. 2022. PMID: 36273494 Free PMC article.
Resistance to therapy caused by intragenic deletion in BRCA2.
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Edwards SL, et al. Among authors: lord cj. Nature. 2008 Feb 28;451(7182):1111-5. doi: 10.1038/nature06548. Epub 2008 Feb 10. Nature. 2008. PMID: 18264088
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, Waldman T, Lord CJ, Ashworth A. Mendes-Pereira AM, et al. Among authors: lord cj. EMBO Mol Med. 2009 Sep;1(6-7):315-22. doi: 10.1002/emmm.200900041. EMBO Mol Med. 2009. PMID: 20049735 Free PMC article.
Therapeutic targeting of the DNA mismatch repair pathway.
Martin SA, Lord CJ, Ashworth A. Martin SA, et al. Among authors: lord cj. Clin Cancer Res. 2010 Nov 1;16(21):5107-13. doi: 10.1158/1078-0432.CCR-10-0821. Epub 2010 Sep 7. Clin Cancer Res. 2010. PMID: 20823149 Review.
Searching for synthetic lethality in cancer.
Brough R, Frankum JR, Costa-Cabral S, Lord CJ, Ashworth A. Brough R, et al. Among authors: lord cj. Curr Opin Genet Dev. 2011 Feb;21(1):34-41. doi: 10.1016/j.gde.2010.10.009. Epub 2011 Jan 20. Curr Opin Genet Dev. 2011. PMID: 21255997 Review.
236 results