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Evasion of cGAS and TRIM5 defines pandemic HIV.
Zuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ. Zuliani-Alvarez L, et al. Among authors: james lc. Nat Microbiol. 2022 Nov;7(11):1762-1776. doi: 10.1038/s41564-022-01247-0. Epub 2022 Oct 26. Nat Microbiol. 2022. PMID: 36289397 Free PMC article.
Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.
Price AJ, Marzetta F, Lammers M, Ylinen LM, Schaller T, Wilson SJ, Towers GJ, James LC. Price AJ, et al. Among authors: james lc. Nat Struct Mol Biol. 2009 Oct;16(10):1036-42. doi: 10.1038/nsmb.1667. Epub 2009 Sep 20. Nat Struct Mol Biol. 2009. PMID: 19767750 Free PMC article.
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.
Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, KewalRamani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ. Schaller T, et al. Among authors: james lc. PLoS Pathog. 2011 Dec;7(12):e1002439. doi: 10.1371/journal.ppat.1002439. Epub 2011 Dec 8. PLoS Pathog. 2011. PMID: 22174692 Free PMC article.
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC. Caines ME, et al. Among authors: james lc. Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6. doi: 10.1038/nsmb.2253. Nat Struct Mol Biol. 2012. PMID: 22407016 Free PMC article.
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.
Price AJ, Fletcher AJ, Schaller T, Elliott T, Lee K, KewalRamani VN, Chin JW, Towers GJ, James LC. Price AJ, et al. Among authors: james lc. PLoS Pathog. 2012;8(8):e1002896. doi: 10.1371/journal.ppat.1002896. Epub 2012 Aug 30. PLoS Pathog. 2012. PMID: 22956906 Free PMC article.
149 results