Crawford JM - Search Results

1

Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites.

Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Cao Y, et al. Among authors: crawford jm. Science. 2022 Oct 28;378(6618):eabm3233. doi: 10.1126/science.abm3233. Epub 2022 Oct 28. Science. 2022. PMID: 36302024 Free PMC article.

2

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

Healy AR, Vizcaino MI, Crawford JM, Herzon SB. Healy AR, et al. Among authors: crawford jm. J Am Chem Soc. 2016 Apr 27;138(16):5426-32. doi: 10.1021/jacs.6b02276. Epub 2016 Apr 12. J Am Chem Soc. 2016. PMID: 27025153 Free PMC article.

3

A Mechanistic Model for Colibactin-Induced Genotoxicity.

Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB. Healy AR, et al. Among authors: crawford jm. J Am Chem Soc. 2016 Dec 7;138(48):15563-15570. doi: 10.1021/jacs.6b10354. Epub 2016 Nov 28. J Am Chem Soc. 2016. PMID: 27934011 Free PMC article.

4

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

Trautman EP, Healy AR, Shine EE, Herzon SB, Crawford JM. Trautman EP, et al. Among authors: crawford jm. J Am Chem Soc. 2017 Mar 22;139(11):4195-4201. doi: 10.1021/jacs.7b00659. Epub 2017 Mar 10. J Am Chem Soc. 2017. PMID: 28240912 Free PMC article.

5

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway.

Guntaka NS, Healy AR, Crawford JM, Herzon SB, Bruner SD. Guntaka NS, et al. Among authors: crawford jm. ACS Chem Biol. 2017 Oct 20;12(10):2598-2608. doi: 10.1021/acschembio.7b00479. Epub 2017 Sep 8. ACS Chem Biol. 2017. PMID: 28846367 Free PMC article.

6

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM. Tripathi P, et al. Among authors: crawford jm. J Am Chem Soc. 2017 Dec 13;139(49):17719-17722. doi: 10.1021/jacs.7b09971. Epub 2017 Nov 28. J Am Chem Soc. 2017. PMID: 29112397 Free PMC article.

7

β-Lactam Biotransformations Activate Innate Immunity.

Oh J, Patel J, Park HB, Crawford JM. Oh J, et al. Among authors: crawford jm. J Org Chem. 2018 Jul 6;83(13):7173-7179. doi: 10.1021/acs.joc.8b00241. Epub 2018 Apr 10. J Org Chem. 2018. PMID: 29616809

8

Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening.

Xue M, Shine E, Wang W, Crawford JM, Herzon SB. Xue M, et al. Among authors: crawford jm. Biochemistry. 2018 Nov 13;57(45):6391-6394. doi: 10.1021/acs.biochem.8b01023. Epub 2018 Oct 31. Biochemistry. 2018. PMID: 30365310 Free PMC article.

9

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.

Shine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM. Shine EE, et al. Among authors: crawford jm. ACS Chem Biol. 2018 Dec 21;13(12):3286-3293. doi: 10.1021/acschembio.8b00714. Epub 2018 Nov 20. ACS Chem Biol. 2018. PMID: 30403848 Free PMC article.

10

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology.

Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. Chen H, et al. Among authors: crawford jm. Cell. 2019 May 16;177(5):1217-1231.e18. doi: 10.1016/j.cell.2019.03.036. Epub 2019 Apr 18. Cell. 2019. PMID: 31006530 Free PMC article.

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