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Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium.
Ziegler CGK, Owings AH, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE 3rd, Senitko M, Robinson TO, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC. Ziegler CGK, et al. Among authors: horwitz bh. medRxiv [Preprint]. 2022 Oct 26:2022.10.25.22281528. doi: 10.1101/2022.10.25.22281528. medRxiv. 2022. PMID: 36324802 Free PMC article. Preprint.
Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.
Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y. Tomalka JA, et al. Among authors: horwitz bh. medRxiv [Preprint]. 2023 Sep 15:2023.09.14.23295549. doi: 10.1101/2023.09.14.23295549. medRxiv. 2023. PMID: 37745424 Free PMC article. Preprint.
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.
Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed J, Ringel A, Barends J, Wu C, Balskus E, Thiagarajah J, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper SB. Bao B, et al. Among authors: horwitz bh. Cell Mol Gastroenterol Hepatol. 2024 May 3:S2352-345X(24)00104-8. doi: 10.1016/j.jcmgh.2024.04.007. Online ahead of print. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38704148 Free article.
COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children.
Tang Y, Boribong BP, Swank ZN, Demokritou M, Luban MAF, Fasano A, Du M, Wolf RL, Griffiths J, Shultz J, Borberg E, Chalise S, Gonzalez WI, Walt DR, Yonker LM, Horwitz BH. Tang Y, et al. Among authors: horwitz bh. medRxiv [Preprint]. 2024 Apr 16:2024.04.15.24305767. doi: 10.1101/2024.04.15.24305767. medRxiv. 2024. PMID: 38699375 Free PMC article. Preprint.
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Ziegler CGK, Owings AH, Galeas-Pena M, Kazer SW, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE 3rd, Senitko M, Robinson TO, Diamond G, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC. Ziegler CGK, et al. Among authors: horwitz bh. Microbiol Spectr. 2024 Jun 4;12(6):e0351623. doi: 10.1128/spectrum.03516-23. Epub 2024 Apr 30. Microbiol Spectr. 2024. PMID: 38687064 Free article.
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane AS, Swank Z, Davis JP, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz BH, McNamara RP, Walt DR, Lauffenburger DA, Julg B, Shreffler WG, Alter G, Yonker LM. Nziza N, et al. Among authors: horwitz bh. Nat Commun. 2024 Jan 30;15(1):905. doi: 10.1038/s41467-024-45181-7. Nat Commun. 2024. PMID: 38291080 Free PMC article.
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB. Tsou AM, et al. Among authors: horwitz bh. Microbiome. 2021 Nov 3;9(1):215. doi: 10.1186/s40168-021-01161-3. Microbiome. 2021. PMID: 34732258 Free PMC article.
67 results