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Unlocking the promise of mRNA therapeutics.
Rohner E, Yang R, Foo KS, Goedel A, Chien KR. Rohner E, et al. Among authors: chien kr. Nat Biotechnol. 2022 Nov;40(11):1586-1600. doi: 10.1038/s41587-022-01491-z. Epub 2022 Nov 3. Nat Biotechnol. 2022. PMID: 36329321 Review.
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.
Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Zangi L, et al. Among authors: chien kr. Nat Biotechnol. 2013 Oct;31(10):898-907. doi: 10.1038/nbt.2682. Epub 2013 Sep 8. Nat Biotechnol. 2013. PMID: 24013197 Free PMC article.
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. Foo KS, et al. Among authors: chien kr. Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17. Mol Ther. 2018. PMID: 29606507 Free PMC article.
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.
Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S. Sun N, et al. Among authors: chien kr. Sci Rep. 2018 Nov 30;8(1):17509. doi: 10.1038/s41598-018-35570-6. Sci Rep. 2018. PMID: 30504800 Free PMC article.
Regenerating the field of cardiovascular cell therapy.
Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. Chien KR, et al. Nat Biotechnol. 2019 Mar;37(3):232-237. doi: 10.1038/s41587-019-0042-1. Epub 2019 Feb 18. Nat Biotechnol. 2019. PMID: 30778231 Review.
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.
Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. Gan LM, et al. Among authors: chien kr. Nat Commun. 2019 Feb 20;10(1):871. doi: 10.1038/s41467-019-08852-4. Nat Commun. 2019. PMID: 30787295 Free PMC article.
340 results