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Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis.
Richoz N, Tuong ZK, Loudon KW, Patiño-Martínez E, Ferdinand JR, Portet A, Bashant KR, Thevenon E, Rucci F, Hoyler T, Junt T, Kaplan MJ, Siegel RM, Clatworthy MR. Richoz N, et al. Among authors: siegel rm. JCI Insight. 2022 Nov 8;7(21):e159751. doi: 10.1172/jci.insight.159751. JCI Insight. 2022. PMID: 36345939 Free PMC article.
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.
Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC, Loudon KW, Banham GD, Mathews RJ, Cader Z, Fitzpatrick S, Bashant KR, Kaplan MJ, Kaser A, Johnson RS, Murphy MP, Siegel RM, Clatworthy MR. Jing C, et al. Among authors: siegel rm. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15160-15171. doi: 10.1073/pnas.2000943117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541026 Free PMC article.
Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.
Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J. Hasni S, et al. Among authors: siegel rm. Arthritis Rheumatol. 2019 Jul;71(7):1135-1140. doi: 10.1002/art.40828. Epub 2019 May 8. Arthritis Rheumatol. 2019. PMID: 30597768 Free PMC article. Clinical Trial.
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.
Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F. Richard AC, et al. Among authors: siegel rm. J Immunol. 2015 Apr 15;194(8):3567-82. doi: 10.4049/jimmunol.1401220. Epub 2015 Mar 18. J Immunol. 2015. PMID: 25786692 Free PMC article.
Natural killer cell expression of Ki67 is associated with elevated serum IL-15, disease activity and nephritis in systemic lupus erythematosus.
Hudspeth K, Wang S, Wang J, Rahman S, Smith MA, Casey KA; Autoimmunity Molecular Team; Manna Z, Sanjuan M, Kolbeck R, Hasni S, Ettinger R, Siegel RM. Hudspeth K, et al. Among authors: siegel rm. Clin Exp Immunol. 2019 May;196(2):226-236. doi: 10.1111/cei.13263. Epub 2019 Mar 19. Clin Exp Immunol. 2019. PMID: 30693467 Free PMC article.
244 results