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Whole-brain microscopy reveals distinct temporal and spatial efficacy of anti-Aβ therapies.
Kirschenbaum D, Dadgar-Kiani E, Catto F, Voigt FF, Trevisan C, Bichsel O, Shirani H, Nilsson KPR, Frontzek KJ, Paganetti P, Helmchen F, Lee JH, Aguzzi A. Kirschenbaum D, et al. Among authors: aguzzi a. EMBO Mol Med. 2023 Jan 11;15(1):e16789. doi: 10.15252/emmm.202216789. Epub 2022 Nov 16. EMBO Mol Med. 2023. PMID: 36382364 Free PMC article.
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.
Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Aslund A, et al. Among authors: aguzzi a. ACS Chem Biol. 2009 Aug 21;4(8):673-84. doi: 10.1021/cb900112v. ACS Chem Biol. 2009. PMID: 19624097 Free PMC article.
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.
Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A. Margalith I, et al. Among authors: aguzzi a. J Biol Chem. 2012 Jun 1;287(23):18872-87. doi: 10.1074/jbc.M112.355958. Epub 2012 Apr 6. J Biol Chem. 2012. PMID: 22493452 Free PMC article.
Structure-based drug design identifies polythiophenes as antiprion compounds.
Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, Caflisch A, Meier BH, Nilsson KP, Hornemann S, Aguzzi A. Herrmann US, et al. Among authors: aguzzi a. Sci Transl Med. 2015 Aug 5;7(299):299ra123. doi: 10.1126/scitranslmed.aab1923. Sci Transl Med. 2015. PMID: 26246168
641 results