Nilsson KPR - Search Results

1

Whole-brain microscopy reveals distinct temporal and spatial efficacy of anti-Aβ therapies.

Kirschenbaum D, Dadgar-Kiani E, Catto F, Voigt FF, Trevisan C, Bichsel O, Shirani H, Nilsson KPR, Frontzek KJ, Paganetti P, Helmchen F, Lee JH, Aguzzi A. Kirschenbaum D, et al. Among authors: nilsson kpr. EMBO Mol Med. 2023 Jan 11;15(1):e16789. doi: 10.15252/emmm.202216789. Epub 2022 Nov 16. EMBO Mol Med. 2023. PMID: 36382364 Free PMC article.

2

Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy.

Nilsson KP, Ikenberg K, Aslund A, Fransson S, Konradsson P, Röcken C, Moch H, Aguzzi A. Nilsson KP, et al. Am J Pathol. 2010 Feb;176(2):563-74. doi: 10.2353/ajpath.2010.080797. Epub 2009 Dec 24. Am J Pathol. 2010. PMID: 20035056 Free PMC article.

3

Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.

Nyström S, Mishra R, Hornemann S, Aguzzi A, Nilsson KP, Hammarström P. Nyström S, et al. J Biol Chem. 2012 Jul 27;287(31):25975-84. doi: 10.1074/jbc.M112.372136. Epub 2012 Jun 5. J Biol Chem. 2012. PMID: 22669942 Free PMC article.

4

The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.

Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP. Klingstedt T, et al. Chemistry. 2013 Jul 29;19(31):10179-92. doi: 10.1002/chem.201301463. Epub 2013 Jun 18. Chemistry. 2013. PMID: 23780508 Free PMC article.

5

Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts.

Simon RA, Shirani H, Aslund KO, Bäck M, Haroutunian V, Gandy S, Nilsson KP. Simon RA, et al. Chemistry. 2014 Sep 22;20(39):12537-43. doi: 10.1002/chem.201402890. Epub 2014 Aug 8. Chemistry. 2014. PMID: 25111601 Free PMC article.

6

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates.

Klingstedt T, Shirani H, Mahler J, Wegenast-Braun BM, Nyström S, Goedert M, Jucker M, Nilsson KP. Klingstedt T, et al. Chemistry. 2015 Jun 15;21(25):9072-82. doi: 10.1002/chem.201500556. Epub 2015 May 26. Chemistry. 2015. PMID: 26013403 Free PMC article.

7

Structure-based drug design identifies polythiophenes as antiprion compounds.

Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, Caflisch A, Meier BH, Nilsson KP, Hornemann S, Aguzzi A. Herrmann US, et al. Sci Transl Med. 2015 Aug 5;7(299):299ra123. doi: 10.1126/scitranslmed.aab1923. Sci Transl Med. 2015. PMID: 26246168

8

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

Shirani H, Linares M, Sigurdson CJ, Lindgren M, Norman P, Nilsson KP. Shirani H, et al. Chemistry. 2015 Oct 19;21(43):15133-7. doi: 10.1002/chem.201502999. Epub 2015 Sep 21. Chemistry. 2015. PMID: 26388448 Free PMC article.

9

Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease.

Shirani H, Appelqvist H, Bäck M, Klingstedt T, Cairns NJ, Nilsson KPR. Shirani H, et al. Among authors: nilsson kpr. Chemistry. 2017 Dec 1;23(67):17127-17135. doi: 10.1002/chem.201703846. Epub 2017 Nov 8. Chemistry. 2017. PMID: 28926133 Free PMC article.

10

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH. Schütz AK, et al. Among authors: nilsson kpr. ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4. ACS Chem Neurosci. 2018. PMID: 29178774

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