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Whole-brain microscopy reveals distinct temporal and spatial efficacy of anti-Aβ therapies.
Kirschenbaum D, Dadgar-Kiani E, Catto F, Voigt FF, Trevisan C, Bichsel O, Shirani H, Nilsson KPR, Frontzek KJ, Paganetti P, Helmchen F, Lee JH, Aguzzi A. Kirschenbaum D, et al. Among authors: paganetti p. EMBO Mol Med. 2023 Jan 11;15(1):e16789. doi: 10.15252/emmm.202216789. Epub 2022 Nov 16. EMBO Mol Med. 2023. PMID: 36382364 Free PMC article.
Acetylation targets mutant huntingtin to autophagosomes for degradation.
Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Jeong H, et al. Among authors: paganetti p. Cell. 2009 Apr 3;137(1):60-72. doi: 10.1016/j.cell.2009.03.018. Cell. 2009. PMID: 19345187 Free PMC article.
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.
Fox JH, Connor T, Chopra V, Dorsey K, Kama JA, Bleckmann D, Betschart C, Hoyer D, Frentzel S, Difiglia M, Paganetti P, Hersch SM. Fox JH, et al. Among authors: paganetti p. Mol Neurodegener. 2010 Jun 22;5:26. doi: 10.1186/1750-1326-5-26. Mol Neurodegener. 2010. PMID: 20569486 Free PMC article.
Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Proenca CC, Stoehr N, Bernhard M, Seger S, Genoud C, Roscic A, Paganetti P, Liu S, Murphy LO, Kuhn R, Bouwmeester T, Galimberti I. Proenca CC, et al. Among authors: paganetti p. PLoS One. 2013 Jul 8;8(7):e68357. doi: 10.1371/journal.pone.0068357. Print 2013. PLoS One. 2013. PMID: 23861892 Free PMC article.
93 results