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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C. Niemeyer D, et al. Among authors: hocke ac. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36383605 Free PMC article.
The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N'Guessan PD, Rosseau S, Suttorp N, Witzenrath M. Müller HC, et al. Among authors: hocke ac. Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23. Pulm Pharmacol Ther. 2011. PMID: 21419858
Allergic lung inflammation induces pulmonary vascular hyperresponsiveness.
Witzenrath M, Ahrens B, Kube SM, Hocke AC, Rosseau S, Hamelmann E, Suttorp N, Schütte H. Witzenrath M, et al. Among authors: hocke ac. Eur Respir J. 2006 Aug;28(2):370-7. doi: 10.1183/09031936.06.00080105. Epub 2006 Mar 29. Eur Respir J. 2006. PMID: 16571613 Free article.
Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs.
Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T. Hocke AC, et al. Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-6. doi: 10.1164/rccm.201305-0954LE. Am J Respir Crit Care Med. 2013. PMID: 24083868 No abstract available.
128 results