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Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil R, O'Shea C, Nykjær A, Bonvin AM, Kragelund BB. Dagil R, et al. Among authors: nykjaer a. J Biol Chem. 2013 Feb 8;288(6):4424-35. doi: 10.1074/jbc.M112.434159. Epub 2012 Dec 27. J Biol Chem. 2013. PMID: 23275343 Free PMC article.
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Goettsch C, et al. Among authors: nykjaer a. J Clin Invest. 2016 Apr 1;126(4):1323-36. doi: 10.1172/JCI80851. Epub 2016 Mar 7. J Clin Invest. 2016. PMID: 26950419 Free PMC article.
131 results