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Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. Allen GM, et al. Among authors: garcia kc. Science. 2022 Dec 16;378(6625):eaba1624. doi: 10.1126/science.aba1624. Epub 2022 Dec 16. Science. 2022. PMID: 36520915 Free PMC article.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC. Weiskopf K, et al. Among authors: garcia kc. Science. 2013 Jul 5;341(6141):88-91. doi: 10.1126/science.1238856. Epub 2013 May 30. Science. 2013. PMID: 23722425 Free PMC article.
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC. Sockolosky JT, et al. Among authors: garcia kc. Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246. Science. 2018. PMID: 29496879 Free PMC article.
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J. Wilmes S, et al. Among authors: garcia kc. Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242. Science. 2020. PMID: 32029621 Free PMC article.
299 results