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Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. Allen GM, et al. Among authors: li aw. Science. 2022 Dec 16;378(6625):eaba1624. doi: 10.1126/science.aba1624. Epub 2022 Dec 16. Science. 2022. PMID: 36520915 Free PMC article.
Engineering cytokines and cytokine circuits.
Li AW, Lim WA. Li AW, et al. Science. 2020 Nov 27;370(6520):1034-1035. doi: 10.1126/science.abb5607. Science. 2020. PMID: 33243875 Free PMC article. No abstract available.
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. Choe JH, et al. Among authors: li aw. Sci Transl Med. 2021 Apr 28;13(591):eabe7378. doi: 10.1126/scitranslmed.abe7378. Sci Transl Med. 2021. PMID: 33910979 Free PMC article.
Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape.
Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Dharmaraj N, et al. Among authors: li aw. Oncoimmunology. 2019 Feb 6;8(4):e1568809. doi: 10.1080/2162402X.2019.1568809. eCollection 2019. Oncoimmunology. 2019. PMID: 30906661 Free PMC article.
Metabolic labeling and targeted modulation of dendritic cells.
Wang H, Sobral MC, Zhang DKY, Cartwright AN, Li AW, Dellacherie MO, Tringides CM, Koshy ST, Wucherpfennig KW, Mooney DJ. Wang H, et al. Among authors: li aw. Nat Mater. 2020 Nov;19(11):1244-1252. doi: 10.1038/s41563-020-0680-1. Epub 2020 May 18. Nat Mater. 2020. PMID: 32424368 Free PMC article.
113 results