Watson MJ - Search Results

1

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity.

Vignali PDA, DePeaux K, Watson MJ, Ye C, Ford BR, Lontos K, McGaa NK, Scharping NE, Menk AV, Robson SC, Poholek AC, Rivadeneira DB, Delgoffe GM. Vignali PDA, et al. Among authors: watson mj. Nat Immunol. 2023 Feb;24(2):267-279. doi: 10.1038/s41590-022-01379-9. Epub 2022 Dec 21. Nat Immunol. 2023. PMID: 36543958 Free PMC article.

2

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM. Menk AV, et al. Among authors: watson mj. J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. Epub 2018 Mar 6. J Exp Med. 2018. PMID: 29511066 Free PMC article.

3

CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.

Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Zappasodi R, et al. Among authors: watson mj. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.

4

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. Watson MJ, et al. Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.

5

Fighting in a wasteland: deleterious metabolites and antitumor immunity.

Watson MJ, Delgoffe GM. Watson MJ, et al. J Clin Invest. 2022 Jan 18;132(2):e148549. doi: 10.1172/JCI148549. J Clin Invest. 2022. PMID: 35040434 Free PMC article. Review.

6

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors.

Lontos K, Wang Y, Joshi SK, Frisch AT, Watson MJ, Kumar A, Menk AV, Wang Y, Cumberland R, Lohmueller J, Carrizosa E, Boyerinas B, Delgoffe GM. Lontos K, et al. Among authors: watson mj. J Immunother Cancer. 2023 Mar;11(3):e006522. doi: 10.1136/jitc-2022-006522. J Immunother Cancer. 2023. PMID: 36914208 Free PMC article.

7

An oncolytic virus-delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment.

DePeaux K, Rivadeneira DB, Lontos K, Dean VG, Gunn WG, Watson MJ, Yao T, Wilfahrt D, Hinck C, Wieteska L, Thorne SH, Hinck AP, Delgoffe GM. DePeaux K, et al. Among authors: watson mj. J Exp Med. 2023 Oct 2;220(10):e20230053. doi: 10.1084/jem.20230053. Epub 2023 Aug 8. J Exp Med. 2023. PMID: 37552475 Free PMC article.

8

Backbone ¹H, ¹³C and ¹⁵N resonance assignment of the ubiquitin specific protease 7 catalytic domain (residues 208-554) in complex with a small molecule ligand.

Pandya MJ, Augustyniak W, Cliff MJ, Lindner I, Stinn A, Kahmann J, Temmerman K, Dannatt HRW, Waltho JP, Watson MJ. Pandya MJ, et al. Among authors: watson mj. Biomol NMR Assign. 2024 Jun;18(1):33-44. doi: 10.1007/s12104-024-10165-7. Epub 2024 Mar 12. Biomol NMR Assign. 2024. PMID: 38472728

9

The novel rapid formulation of intravenous dantrolene (NPJ5008) versus standard dantrolene (Dantrium®): A clinical part-randomised phase 1 study in healthy volunteers.

Ng Kwet Shing RH, Clayton LB, Smith SL, Watson MJ, McKenzie LM, Chalmers DP, Whitaker G, Bilmen JG. Ng Kwet Shing RH, et al. Among authors: watson mj. Eur J Anaesthesiol. 2024 May 1;41(5):381-390. doi: 10.1097/EJA.0000000000001966. Epub 2024 Mar 5. Eur J Anaesthesiol. 2024. PMID: 38445365 Free PMC article. Clinical Trial.

10

Combinatorial immune refocusing within the influenza hemagglutinin RBD improves cross-neutralizing antibody responses.

Dosey A, Ellis D, Boyoglu-Barnum S, Syeda H, Saunders M, Watson MJ, Kraft JC, Pham MN, Guttman M, Lee KK, Kanekiyo M, King NP. Dosey A, et al. Among authors: watson mj. Cell Rep. 2023 Dec 26;42(12):113553. doi: 10.1016/j.celrep.2023.113553. Epub 2023 Dec 13. Cell Rep. 2023. PMID: 38096052 Free PMC article.

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