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RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A. Sugawara S, et al. Among authors: nagayama s. Commun Biol. 2022 Dec 28;5(1):1420. doi: 10.1038/s42003-022-04369-7. Commun Biol. 2022. PMID: 36577784 Free PMC article.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Miyata K, Imai Y, Hori S, Nishio M, Loo TM, Okada R, Yang L, Nakadai T, Maruyama R, Fujii R, Ueda K, Jiang L, Zheng H, Toyokuni S, Sakata T, Shirahige K, Kojima R, Nakayama M, Oshima M, Nagayama S, Seimiya H, Hirota T, Saya H, Hara E, Takahashi A. Miyata K, et al. Among authors: nagayama s. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025647118. doi: 10.1073/pnas.2025647118. Proc Natl Acad Sci U S A. 2021. PMID: 34426493 Free PMC article.
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E. Okumura S, et al. Among authors: nagayama s. Nat Commun. 2021 Sep 28;12(1):5674. doi: 10.1038/s41467-021-25965-x. Nat Commun. 2021. PMID: 34584098 Free PMC article.
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.
Saito T, Niida A, Uchi R, Hirata H, Komatsu H, Sakimura S, Hayashi S, Nambara S, Kuroda Y, Ito S, Eguchi H, Masuda T, Sugimachi K, Tobo T, Nishida H, Daa T, Chiba K, Shiraishi Y, Yoshizato T, Kodama M, Okimoto T, Mizukami K, Ogawa R, Okamoto K, Shuto M, Fukuda K, Matsui Y, Shimamura T, Hasegawa T, Doki Y, Nagayama S, Yamada K, Kato M, Shibata T, Mori M, Aburatani H, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K. Saito T, et al. Among authors: nagayama s. Nat Commun. 2018 Jul 23;9(1):2884. doi: 10.1038/s41467-018-05226-0. Nat Commun. 2018. PMID: 30038269 Free PMC article.
Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer.
Okamoto T, duVerle D, Yaginuma K, Natsume Y, Yamanaka H, Kusama D, Fukuda M, Yamamoto M, Perraudeau F, Srivastava U, Kashima Y, Suzuki A, Kuze Y, Takahashi Y, Ueno M, Sakai Y, Noda T, Tsuda K, Suzuki Y, Nagayama S, Yao R. Okamoto T, et al. Among authors: nagayama s. Stem Cell Reports. 2021 Apr 13;16(4):954-967. doi: 10.1016/j.stemcr.2021.02.012. Epub 2021 Mar 11. Stem Cell Reports. 2021. PMID: 33711267 Free PMC article.
396 results