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Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.
Vieira V, Lim N, Singh A, Leitman E, Dsouza R, Adland E, Muenchhoff M, Roider J, Marin Lopez M, Carabelli J, Giandhari J, Groll A, Jooste P, Prado JG, Thobakgale C, Dong K, Kiepiela P, Prendergast AJ, Tudor-Williams G, Frater J, Walker BD, Ndung'u T, Ramsuran V, Leslie A, Kløverpris HN, Goulder P. Vieira V, et al. Among authors: goulder p. JCI Insight. 2023 Feb 8;8(3):e156049. doi: 10.1172/jci.insight.156049. JCI Insight. 2023. PMID: 36602861 Free PMC article.
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, Dong K, Kiepiela P, Coovadia H, Ndung'u T, Walker BD, Goulder PJ. Thobakgale CF, et al. Among authors: goulder pj. J Virol. 2009 Oct;83(19):10234-44. doi: 10.1128/JVI.00921-09. Epub 2009 Jul 15. J Virol. 2009. PMID: 19605475 Free PMC article.
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
Thobakgale CF, Streeck H, Mkhwanazi N, Mncube Z, Maphumulo L, Chonco F, Prendergast A, Tudor-Williams G, Walker BD, Goulder PJ, Altfeld M, Ndung'u T. Thobakgale CF, et al. AIDS Res Hum Retroviruses. 2011 Sep;27(9):1005-12. doi: 10.1089/AID.2010.0227. Epub 2011 Mar 21. AIDS Res Hum Retroviruses. 2011. PMID: 21288139 Free PMC article.
Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.
Leitman EM, Thobakgale CF, Adland E, Ansari MA, Raghwani J, Prendergast AJ, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, Ndung'u T, Walker BD, Pybus OG, Kellam P, Naranbhai V, Matthews PC, Gall A, Goulder PJR. Leitman EM, et al. Among authors: goulder pjr. J Exp Med. 2017 Nov 6;214(11):3239-3261. doi: 10.1084/jem.20162123. Epub 2017 Oct 5. J Exp Med. 2017. PMID: 28983013 Free PMC article.
An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.
Vieira VA, Adland E, Malone DFG, Martin MP, Groll A, Ansari MA, Garcia-Guerrero MC, Puertas MC, Muenchhoff M, Guash CF, Brander C, Martinez-Picado J, Bamford A, Tudor-Williams G, Ndung'u T, Walker BD, Ramsuran V, Frater J, Jooste P, Peppa D, Carrington M, Goulder PJR. Vieira VA, et al. Among authors: goulder pjr. PLoS Pathog. 2021 Nov 18;17(11):e1010090. doi: 10.1371/journal.ppat.1010090. eCollection 2021 Nov. PLoS Pathog. 2021. PMID: 34793581 Free PMC article.
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD. Day CL, et al. Among authors: goulder pj. Nature. 2006 Sep 21;443(7109):350-4. doi: 10.1038/nature05115. Epub 2006 Aug 20. Nature. 2006. PMID: 16921384
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
Thobakgale CF, Ramduth D, Reddy S, Mkhwanazi N, de Pierres C, Moodley E, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Kindra G, Bobat R, Coovadia H, Kiepiela P, Walker BD, Goulder PJ. Thobakgale CF, et al. Among authors: goulder pj. J Virol. 2007 Dec;81(23):12775-84. doi: 10.1128/JVI.00624-07. Epub 2007 Sep 19. J Virol. 2007. PMID: 17881456 Free PMC article.
Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
Ramduth D, Thobakgale CF, Mkhwanazi NP, De Pierres C, Reddy S, van der Stok M, Mncube Z, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Coovadia HM, Day CL, Kiepiela P, Goulder PJ, Walker BD. Ramduth D, et al. Among authors: goulder pj. AIDS Res Hum Retroviruses. 2008 Feb;24(2):265-70. doi: 10.1089/aid.2007.0096. AIDS Res Hum Retroviruses. 2008. PMID: 18284325
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, Walker BD. Ramduth D, et al. Among authors: goulder pj. PLoS One. 2009;4(4):e5013. doi: 10.1371/journal.pone.0005013. Epub 2009 Apr 7. PLoS One. 2009. PMID: 19352428 Free PMC article.
315 results