Ambudkar SV - Search Results

1

Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment-Contributions of Polar and Non-Polar Interactions.

Moreno MJ, Filipe HAL, Cunha SVP, Ramos CV, Martins PAT, Abel B, Loura LMS, Ambudkar SV. Moreno MJ, et al. Among authors: ambudkar sv. Pharmaceutics. 2023 Jan 3;15(1):174. doi: 10.3390/pharmaceutics15010174. Pharmaceutics. 2023. PMID: 36678803 Free PMC article.

2

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV. Shukla S, et al. Among authors: ambudkar sv. Mol Pharm. 2011 Aug 1;8(4):1292-302. doi: 10.1021/mp2001022. Epub 2011 Jun 16. Mol Pharm. 2011. PMID: 21630681 Free PMC article.

3

Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approach.

Shukla S, Kouanda A, Silverton L, Talele TT, Ambudkar SV. Shukla S, et al. Among authors: ambudkar sv. Mol Pharm. 2014 Jul 7;11(7):2313-22. doi: 10.1021/mp400762h. Epub 2014 Jun 5. Mol Pharm. 2014. PMID: 24865254 Free PMC article.

4

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.

Shukla S, Abel B, Chufan EE, Ambudkar SV. Shukla S, et al. Among authors: ambudkar sv. J Biol Chem. 2017 Apr 28;292(17):7066-7076. doi: 10.1074/jbc.M116.771634. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283574 Free PMC article.

5

Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter.

Wu CP, Hsiao SH, Murakami M, Lu YJ, Li YQ, Huang YH, Hung TH, Ambudkar SV, Wu YS. Wu CP, et al. Among authors: ambudkar sv. Mol Pharm. 2017 Aug 7;14(8):2805-2814. doi: 10.1021/acs.molpharmaceut.7b00334. Epub 2017 Jul 5. Mol Pharm. 2017. PMID: 28641010 Free PMC article.

6

Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT. Patel BA, et al. Among authors: ambudkar sv. J Med Chem. 2018 Feb 8;61(3):834-864. doi: 10.1021/acs.jmedchem.7b01340. Epub 2018 Jan 23. J Med Chem. 2018. PMID: 29251928 Free PMC article.

7

Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.

Sugisawa N, Ohnuma S, Ueda H, Murakami M, Sugiyama K, Ohsawa K, Kano K, Tokuyama H, Doi T, Aoki J, Ishida M, Kudoh K, Naitoh T, Ambudkar SV, Unno M. Sugisawa N, et al. Among authors: ambudkar sv. Mol Pharm. 2018 Sep 4;15(9):4021-4030. doi: 10.1021/acs.molpharmaceut.8b00457. Epub 2018 Aug 13. Mol Pharm. 2018. PMID: 30052463 Free PMC article.

8

Evidence for the Interaction of A₃ Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1).

Abel B, Tosh DK, Durell SR, Murakami M, Vahedi S, Jacobson KA, Ambudkar SV. Abel B, et al. Among authors: ambudkar sv. Mol Pharmacol. 2019 Aug;96(2):180-192. doi: 10.1124/mol.118.115295. Epub 2019 May 24. Mol Pharmacol. 2019. PMID: 31127007 Free PMC article.

9

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein.

Sajid A, Lusvarghi S, Murakami M, Chufan EE, Abel B, Gottesman MM, Durell SR, Ambudkar SV. Sajid A, et al. Among authors: ambudkar sv. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29609-29617. doi: 10.1073/pnas.2016270117. Epub 2020 Nov 9. Proc Natl Acad Sci U S A. 2020. PMID: 33168729 Free PMC article.

10

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein.

Moreno MJ, Teles Martins PA, Bernardino EF, Abel B, Ambudkar SV. Moreno MJ, et al. Among authors: ambudkar sv. Biomolecules. 2021 Mar 14;11(3):426. doi: 10.3390/biom11030426. Biomolecules. 2021. PMID: 33799403 Free PMC article.

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