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Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Ripa L, Sandmark J, Hughes G, Shamovsky I, Gunnarsson A, Johansson J, Llinas A, Collins M, Jung B, Novén A, Pemberton N, Mogemark M, Xiong Y, Li Q, Tångefjord S, Ek M, Åstrand A. Ripa L, et al. J Med Chem. 2023 Oct 26;66(20):14188-14207. doi: 10.1021/acs.jmedchem.3c01269. Epub 2023 Oct 5. J Med Chem. 2023. PMID: 37797307
Segmental Dynamics of Membranous Cholesterol are Coupled.
Della Ripa LA, Courtney JM, Phinney SM, Borcik CG, Burke MD, Rienstra CM, Pogorelov TV. Della Ripa LA, et al. J Am Chem Soc. 2023 Jul 19;145(28):15043-15048. doi: 10.1021/jacs.3c01775. Epub 2023 Jul 6. J Am Chem Soc. 2023. PMID: 37410392
Steinernema carpocapsae.
Stefanovska T, Luckhart S, Ripa L, Stevens G, Lewis E. Stefanovska T, et al. Among authors: ripa l. Trends Parasitol. 2023 May;39(5):400-401. doi: 10.1016/j.pt.2023.01.002. Epub 2023 Jan 21. Trends Parasitol. 2023. PMID: 36682940 No abstract available.
HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD.
Horndahl J, Svärd R, Berntsson P, Wingren C, Li J, Abdillahi SM, Ghosh B, Capodanno E, Chan J, Ripa L, Åstrand A, Sidhaye VK, Collins M. Horndahl J, et al. Among authors: ripa l. PLoS One. 2022 Oct 12;17(10):e0266310. doi: 10.1371/journal.pone.0266310. eCollection 2022. PLoS One. 2022. PMID: 36223404 Free PMC article.
Advances in the design of new types of inhaled medicines.
Czechtizky W, Su W, Ripa L, Schiesser S, Höijer A, Cox RJ. Czechtizky W, et al. Among authors: ripa l. Prog Med Chem. 2022;61:93-162. doi: 10.1016/bs.pmch.2022.04.001. Epub 2022 Jun 2. Prog Med Chem. 2022. PMID: 35753716 Review.
Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
Di Fruscia P, Edfeldt F, Shamovsky I, Collie GW, Aagaard A, Barlind L, Börjesson U, Hansson EL, Lewis RJ, Nilsson MK, Öster L, Pemberton J, Ripa L, Storer RI, Käck H. Di Fruscia P, et al. Among authors: ripa l. ACS Med Chem Lett. 2021 Jan 27;12(2):302-308. doi: 10.1021/acsmedchemlett.0c00563. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603979 Free PMC article.
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
Munck Af Rosenschöld M, Johannesson P, Nikitidis A, Tyrchan C, Chang HF, Rönn R, Chapman D, Ullah V, Nikitidis G, Glader P, Käck H, Bonn B, Wågberg F, Björkstrand E, Andersson U, Swedin L, Rohman M, Andreasson T, Bergström EL, Jiang F, Zhou XH, Lundqvist AJ, Malmberg A, Ek M, Gordon E, Pettersen A, Ripa L, Davis AM. Munck Af Rosenschöld M, et al. Among authors: ripa l. J Med Chem. 2019 Sep 12;62(17):7769-7787. doi: 10.1021/acs.jmedchem.9b00555. Epub 2019 Aug 30. J Med Chem. 2019. PMID: 31415176
147 results