Higgins GS - Search Results

1

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland HR, Millar V, Ebner D, Boursier M, Cerutti A, Cicconi A, Galbiati A, Grande D, Grinkevich V, Majithiya JB, Piscitello D, Rajendra E, Stockley ML, Boulton SJ, Hammond EM, Heald RA, Smith GCM, Robinson HMR, Higgins GS. Rodriguez-Berriguete G, et al. Among authors: higgins gs. Clin Cancer Res. 2023 Apr 14;29(8):1631-1642. doi: 10.1158/1078-0432.CCR-22-2977. Clin Cancer Res. 2023. PMID: 36689546 Free PMC article.

2

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

Higgins GS, Prevo R, Lee YF, Helleday T, Muschel RJ, Taylor S, Yoshimura M, Hickson ID, Bernhard EJ, McKenna WG. Higgins GS, et al. Cancer Res. 2010 Apr 1;70(7):2984-93. doi: 10.1158/0008-5472.CAN-09-4040. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233878 Free PMC article.

3

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

Higgins GS, Harris AL, Prevo R, Helleday T, McKenna WG, Buffa FM. Higgins GS, et al. Oncotarget. 2010 Jul;1(3):175-84. doi: 10.18632/oncotarget.124. Oncotarget. 2010. PMID: 20700469 Free PMC article.

4

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity.

Fokas E, Yoshimura M, Prevo R, Higgins G, Hackl W, Maira SM, Bernhard EJ, McKenna WG, Muschel RJ. Fokas E, et al. Radiat Oncol. 2012 Mar 27;7:48. doi: 10.1186/1748-717X-7-48. Radiat Oncol. 2012. PMID: 22452803 Free PMC article.

5

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.

Tiwana GS, Prevo R, Buffa FM, Yu S, Ebner DV, Howarth A, Folkes LK, Budwal B, Chu KY, Durrant L, Muschel RJ, McKenna WG, Higgins GS. Tiwana GS, et al. Among authors: higgins gs. Oncotarget. 2015 Mar 20;6(8):5978-89. doi: 10.18632/oncotarget.3468. Oncotarget. 2015. PMID: 25788274 Free PMC article.

6

In Vitro-Pooled shRNA Screening to Identify Determinants of Radiosensitivity.

Ceroni A, Higgins GS, Ebner DV. Ceroni A, et al. Among authors: higgins gs. Methods Mol Biol. 2016;1470:103-19. doi: 10.1007/978-1-4939-6337-9_9. Methods Mol Biol. 2016. PMID: 27581288

7

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity.

Sayal KK, Higgins GS, Hammond EM. Sayal KK, et al. Among authors: higgins gs. Ann Transl Med. 2016 Dec;4(24):538. doi: 10.21037/atm.2016.11.65. Ann Transl Med. 2016. PMID: 28149899 Free PMC article. No abstract available.

8

Depletion of signal recognition particle 72kDa increases radiosensitivity.

Prevo R, Tiwana GS, Maughan TS, Buffa FM, McKenna WG, Higgins GS. Prevo R, et al. Among authors: higgins gs. Cancer Biol Ther. 2017 Jun 3;18(6):425-432. doi: 10.1080/15384047.2017.1323587. Epub 2017 May 11. Cancer Biol Ther. 2017. PMID: 28494188 Free PMC article.

9

Beyond PARP-POLθ as an anticancer target.

Higgins GS, Boulton SJ. Higgins GS, et al. Science. 2018 Mar 16;359(6381):1217-1218. doi: 10.1126/science.aar5149. Science. 2018. PMID: 29590065 No abstract available.

10

Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.

Rodriguez-Berriguete G, Granata G, Puliyadi R, Tiwana G, Prevo R, Wilson RS, Yu S, Buffa F, Humphrey TC, McKenna WG, Higgins GS. Rodriguez-Berriguete G, et al. Among authors: higgins gs. Nucleic Acids Res. 2018 Sep 6;46(15):7731-7746. doi: 10.1093/nar/gky569. Nucleic Acids Res. 2018. PMID: 29986057 Free PMC article.

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